The trehalose myth revisited: Introduction to a symposium on stabilization of cells in the dry state
The trehalose myth revisited: Introduction to a symposium on stabilization of cells in the dry state
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DOI：
10.1006/cryo.2001.2353
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发表时间：
2001-09-01
期刊：
影响因子：
2.7
通讯作者：
Tablin, F
中科院分区：
文献类型：
--
作者：
Crowe, JH;Crowe, LM;Tablin, F
本文介绍了一系列论文所产生的研讨会上稳定的细胞在干燥状态。几乎所有这些研究都利用糖海藻糖作为稳定分子。在过去的二十年里，关于海藻糖稳定生物材料的特殊性质的神话已经成长起来。我们在这里回顾了许多这样的用途，并表明在干燥和储存的理想条件下，海藻糖几乎没有任何性质。然而，在次优条件下，海藻糖具有一些明显的优势，因此可能仍然是优选的赋形剂。我们回顾了将海藻糖引入活细胞细胞质的可用机制，作为以下论文的介绍。(C)2001 Elsevier Science（美国）。
This essay is an introduction to a series of papers arising from a symposium on stabilization of cells in the dry state. Nearly all of these investigations have utilized the sugar trehalose as a stabilizing molecule. Over the past two decades a myth has grown up about special properties of trehalose for stabilization of biomaterials. We review many of such uses here and show that under ideal conditions for drying and storage trehalose has few, if any, properties. However, under suboptimal conditions trehalose has some distinct advantages and thus may remain the preferred excipient. We review the available mechanisms for introducing trehalose into the cytoplasm of living cells as an introduction to the papers that follow. (C) 2001 Elsevier Science (USA).