Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence
Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence
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DOI：
10.1038/npp.2015.214
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发表时间：
2016-02-01
影响因子：
7.6
通讯作者：
DeVito, Anthony M.
中科院分区：
文献类型：
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作者：
McClernon, F. Joseph;Conklin, Cynthia A.;DeVito, Anthony M.
与先前药物使用相关的环境会引发渴望和吸毒，并为失效/复发奠定基础。虽然环境诱导的药物服用的神经行为基础已经用动物模型进行了研究，但药物环境对药物使用者临床人群的脑功能和行为的影响在很大程度上尚未探索。成年吸烟者（n = 40）拍摄个人与吸烟（个人吸烟环境; PSE）或个人非吸烟环境（PNEs）的位置。24小时戒烟后，参与者进行fMRI扫描，同时查看PSE，PNE，标准吸烟和非吸烟环境，以及近端吸烟（例如，点燃香烟）和非吸烟（例如，铅笔）线索。最后，在两个单独的会议后，6小时的禁欲，他们看到的PSE或PNE，而线索诱导的自我报告的渴望和吸烟行为进行了评估。观察PSE可增加右后海马血氧水平依赖性信号（pHPC; F-2，F-685 = 3.74，p
Environments associated with prior drug use provoke craving and drug taking, and set the stage for lapse/relapse. Although the neurobehavioral bases of environment-induced drug taking have been investigated with animal models, the influence of drug-environments on brain function and behavior in clinical populations of substance users is largely unexplored. Adult smokers (n= 40) photographed locations personally associated with smoking (personal smoking environments; PSEs) or personal nonsmoking environment (PNEs). Following 24-h abstinence, participants underwent fMRI scanning while viewing PSEs, PNEs, standard smoking and nonsmoking environments, as well as proximal smoking (eg, lit cigarette) and nonsmoking (eg, pencil) cues. Finally, in two separate sessions following 6-h abstinence they viewed either PSEs or PNEs while cue-induced self-reported craving and smoking behavior were assessed. Viewing PSEs increased blood oxygen level-dependent signal in right posterior hippocampus (pHPC; F-2,F-685 = 3.74, p