New perspectives on the roles of Abl tyrosine kinase in axon patterning.
New perspectives on the roles of Abl tyrosine kinase in axon patterning.
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关于 Abl 酪氨酸激酶在轴突模式中的作用的新观点。
DOI：
10.1080/19336934.2017.1327106
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发表时间：
2017
期刊：
影响因子：
1.2
通讯作者：
Giniger,Edward
中科院分区：
文献类型：
--
作者：
Kannan,Ramakrishnan;Giniger,Edward
Abelson酪氨酸激酶（Abl）是一小部分普遍存在的保守信号转导通路的核心，这些通路在发育和生理学中起着重要作用。Abl信号传导对于上皮完整性、自主细胞如血细胞的运动性以及神经系统中的轴突生长和引导是必不可少的。然而，尽管Abl是最早被发现的保守信号机器之一，但它是最后阐明其基本结构的机器之一。在这里，我们将首先讨论一些挑战，长期推迟解剖这条途径，以及他们告诉我们什么样的特殊问题，调查动态过程，如运动。然后，我们将描述我们最近的实验，揭示了果蝇神经元的Abl通路的功能组织。最后，在第二部分的审查，我们将介绍一种不同的复杂性的Abl在运动中的作用：发现一个以前不受重视的功能蛋白质分泌和贩运。我们将提供证据表明，Abl的分泌功能也有助于其在轴突生长和指导中的作用，最后结束讨论Abl多效性为研究者提供的挑战，但它提供了协调生物调节的机会。
The Abelson tyrosine kinase (Abl) lies at the heart of one of the small set of ubiquitous, conserved signal transduction pathways that do much of the work of development and physiology. Abl signaling is essential to epithelial integrity, motility of autonomous cells such as blood cells, and axon growth and guidance in the nervous system. However, though Abl was one of the first of these conserved signaling machines to be identified, it has been among the last to have its essential architecture elucidated. Here we will first discuss some of the challenges that long delayed the dissection of this pathway, and what they tell us about the special problems of investigating dynamic processes like motility. We will then describe our recent experiments that revealed the functional organization of the Abl pathway in Drosophila neurons. Finally, in the second part of the review we will introduce a different kind of complexity in the role of Abl in motility: the discovery of a previously unappreciated function in protein secretion and trafficking. We will provide evidence that the secretory function of Abl also contributes to its role in axon growth and guidance, and finally end with a discussion of the challenges that Abl pleiotropy provide for the investigator, but the opportunities that it provides for coordinating biological regulation.