Induction of pancreatic duct of carcinomas in the Syrian hamster with 2,6-dimethylnitrosomorpholine.
Induction of pancreatic duct of carcinomas in the Syrian hamster with 2,6-dimethylnitrosomorpholine.
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用 2,6-二甲基亚硝基吗啉诱导叙利亚仓鼠胰管癌。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
W. Lijinsky
中科院分区：
文献类型：
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作者：
U. Mohr;G. Reznik;E. Emminger;W. Lijinsky
用2，6-二甲基亚硝吗啉灌胃诱发叙利亚仓鼠胰腺癌模型。早在治疗开始后30周，肉眼就可以看到胰腺中的肿瘤；到实验结束时，此类肿瘤的最高发生率达到71%。肿瘤起源于导管，部分转移至肺。它们在组织学上被鉴定为腺瘤和癌，并在器官的不同部位发生，但没有表现出任何首选的定位。
Pancreatic duct carcinomas were induced in Syrian hamsters by intragastric administration of 2,6-dimethylnitrosomorpholine. As early as 30 weeks after treatment began, tumors were macroscopically visible in the pancreas; the maximum incidence of such tumors reached 71% by the end of the experiment. They were ductal in origin, and some metastasized to the lung. They were identified histologically as adenomas and carcinomas and developed in different parts of the organ without demonstrating any preferred localization.