Characteristic Age Distribution of Plasmodium vivax Infections after Malaria Elimination on Aneityum Island, Vanuatu
Characteristic Age Distribution of Plasmodium vivax Infections after Malaria Elimination on Aneityum Island, Vanuatu
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DOI：
10.1128/iai.00931-13
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发表时间：
2014-01-01
影响因子：
3.1
通讯作者：
Drakeley, Chris
中科院分区：
文献类型：
--
作者：
Kaneko, Akira;Chaves, Luis F.;Drakeley, Chris
疟疾消灭后的一个主要问题是疟疾的死灰复燃。1991年在Aneityum岛开始消灭方案后，显微镜检查显示恶性疟原虫立即消失，而间日疟原虫从1996年起消失，直到2002年1月报告了间日疟原虫病例。通过对Aneityum的整个人口进行疟疾计量调查，我们调查了在抗疟抗体水平和寄生虫抗原多样性的背景下，在这种流行病中寄生虫感染者的年龄分布。2002年7月，通过显微镜在22/759人中检测到间日疟原虫感染：1991年消除计划开始后出生的20/298人，1982年至1991年出生的2/126人，1982年之前出生的335人中没有人。聚合酶链反应将检测到的感染人数增加到77人，分布在所有年龄组。患病率分别为12.1%、16.7%和6.0%（P
Resurgence is a major concern after malaria elimination. After the initiation of the elimination program on Aneityum Island in 1991, microscopy showed that Plasmodium falciparum disappeared immediately, whereas P. vivax disappeared from 1996 onward, until P. vivax cases were reported in January 2002. By conducting malariometric surveys of the entire population of Aneityum, we investigated the age distribution of individuals with parasites during this epidemic in the context of antimalarial antibody levels and parasite antigen diversity. In July 2002, P. vivax infections were detected by microscopy in 22/759 individuals: 20/298 born after the beginning of the elimination program in 1991, 2/126 born between 1982 and 1991, and none of 335 born before 1982. PCR increased the number of infections detected to 77, distributed among all age groups. Prevalences were 12.1%, 16.7%, and 6.0%, respectively (P