Estimating the age of the common ancestor of a DNA sample using the number of segregating sites.
Estimating the age of the common ancestor of a DNA sample using the number of segregating sites.
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使用分离位点的数量估计 DNA 样本共同祖先的年龄。
DOI：
10.1093/genetics/144.2.829
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发表时间：
1996
期刊：
影响因子：
3.3
通讯作者：
Fu,YX
中科院分区：
文献类型：
--
作者：
Fu,YX
DNA序列样本中分离位点的数量与样本中序列的最近共同祖先（MRCA）的年龄呈正相关。前者的价值可以用来估计后者的价值。本文利用结合方法，在中性Wright-Fisher模型下，导出了一个样本的分离位点数和MRCA年龄的联合概率分布。根据该分布，我们能够计算分离位点数量的似然函数和样本MRCA年龄的后验概率。三个点估计和一个区间估计的年龄的MRCA的发展，他们的关系和性质进行了研究。本文讨论了从无变异样本中估计人类Y染色体MRCA年龄的问题。
The number of segregating sites in a sample of DNA sequences and the age of the most recent common ancestor (MRCA) of the sequences in the sample are positively correlated. The value of the former can be used to estimate the value of the latter. Using the coalescent approach, we derive in this paper the joint probability distribution of the number of segregating sites and the age of the MRCA of a sample under the neutral Wright-Fisher model. From this distribution, we are able to compute the likelihood function of the number of segregating sites and the posterior probability of the age of the MRCA of a sample. Three point estimators and one interval estimator of the age of the MRCA are developed; their relationships and properties are investigated. The estimation of the age of the MRCA of humanYchromosomes from a sample of no variation is discussed.