Epigenetic Mechanism Involved in the HBV/HCV-Related Hepatocellular Carcinoma Tumorigenesis
Epigenetic Mechanism Involved in the HBV/HCV-Related Hepatocellular Carcinoma Tumorigenesis
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DOI：
10.2174/13816128113199990533
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发表时间：
2014-04-01
影响因子：
3.1
通讯作者：
Jiang Shiwen
中科院分区：
文献类型：
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作者：
Liang Rongrui;Huang Na;Jiang Shiwen
乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染被认为是HCC的危险因素，它们被怀疑通过引起表观遗传改变来促进HCC的发展。然而，精确的基因靶点和潜在的机制尚未阐明。基因表达的表观遗传调控已经成为癌症发展和进展的一个基本方面。肝细胞癌发生的分子机制涉及遗传和表观遗传因素的复杂相互作用。DNA甲基化、组蛋白翻译后修饰、染色质重塑和非编码rna是表观遗传学领域的四种主要机制层。HBV感染可影响p16（INK4A）、GSTP1、CDH1（E-cadherin）、RASSF1A、p21（WAF1/CIP1）基因的甲基化，这些基因可能在HCC的发生发展中发挥重要作用。HCV感染与SOCS-1、Gadd45 β、MGMT、STAT1和APC的异常甲基化有关。其他表观遗传改变包括组蛋白、染色质重塑和非编码rna在文献中被描述。揭示HBV/ hcv诱导的HCC癌变的表观遗传改变可能为破解HCC肿瘤发生和发展机制提供新的策略，以及潜在的诊断优势。
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were known to be risk factors for HCC, they were suspected to promote its development by eliciting epigenetic changes. However, the precise gene targets and underlying mechanisms have not been elucidated. Epigenetic regulation of gene expression has emerged as a fundamental aspect of cancer development and progression. The molecular mechanisms of carcinogenesis in hepatocellular carcinoma involve a complex interplay of both genetic and epigenetic factors. DNA methylation, post-translational modifications of histone proteins, chromatin remodeling, and noncoding RNAs are four major types of mechanistic layers in the field of epigenetics. HBV infection could affect methylation on p16(INK4A), GSTP1, CDH1(E-cadherin), RASSF1A, p21(WAF1/CIP1) genes, which may play important roles in the development of HCC. HCV infection was related to aberrant methylation on SOCS-1, Gadd45 beta, MGMT, STAT1 and APC. Other epigenetic alterations included histone proteins, chromatin remodeling, and noncoding RNAs were described in literature. Uncovering the epigenetic alterations of HBV/HCV-induced HCC carcinogenesis could highlight a new strategy for deciphering the mechanism of HCC tumorigenesis and development, as well as a potential diagnostic advantage.