Jumping genes meet abdominal bristles: hybrid dysgenesis-induced quantitative variation in Drosophila melanogaster
Jumping genes meet abdominal bristles: hybrid dysgenesis-induced quantitative variation in Drosophila melanogaster
复制标题
跳跃基因遇到腹部刚毛：杂交发育不全引起的果蝇数量变异
DOI：
10.1017/s0016672300026422
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发表时间：
1984
影响因子：
1.5
通讯作者：
T. Mackay
中科院分区：
文献类型：
--
作者：
T. Mackay
当一个黑腹果蝇品系(Bingham，Kid Well&Rubin，1982)的雄性与缺乏这些元素的品系(‘M’品系)的雌性品系(‘M’品系)杂交时，F1后代表现出许多被统称为杂交不育的异常特征(Kidwell，Kidwell&Sve，1977)。正反交(P♀×♂M)后代正常。发育不良综合征的特征是由于P元素的加强易位而导致的基因组高度不稳定。由于在无性杂交中经常观察到可见基因的突变和染色体重排，推测这一现象可以用来研究转座对数量性状的影响；因此，人工选择无性杂交和非无性杂交的后代作为腹毛数量高和低的选择。与非遗传对照相比，不育系对选择的反应、表型变异和实现遗传力都有所增加。推测这些特征是P元素诱导影响刷毛数量的基因座突变的结果，未来的工作将导致这些基因座的鉴定，以及阐明易位在度量性状群体分化中的作用
When males from a strain of Drosophila melanogaster which have multiple copies of the P family of transposable elements integrated into their genome (Bingham, Kid well & Rubin, 1982) (‘P’ strains) are crossed to females of strains lacking those elements (‘M’ strains), the F1 progeny manifest a number of aberrant traits known collectively as hybrid dysgenesis (Kidwell, Kidwell & Sved, 1977). Progeny of the reciprocal cross (P♀ × ♂M) are normal. The dysgenic syndrome is characterized by a high degree of genomic instability caused by enhanced transposition of P elements. Since mutations at visible loci and chromosomal rearrangements are frequently observed in dysgenic hybrids, it was hypothesized that this phenomenon could be used to investigate the effects of transposition on quantitative characters; therefore, the progeny of dysgenic and non-dysgenic crosses were artificially selected for high and low abdominal bristle number. The response to selection, phenotypic variation, and realized heritability were all increased in the dysgenic lines, relative to the non-dysgenic control. It is postulated that these features are the result of P element-induced mutations of loci affecting bristle number, and that future work should lead to the identification of these loci, as well as elucidating the role of transposition in population differentiation for metric traits