Greater depressive symptoms, cognition, and markers of brain aging Northern Manhattan Study
Greater depressive symptoms, cognition, and markers of brain aging Northern Manhattan Study
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DOI：
10.1212/wnl.0000000000005639
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发表时间：
2018-06-05
期刊：
影响因子：
9.9
通讯作者：
Wright, Clinton B.
中科院分区：
文献类型：
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作者：
Al Hazzouri, Adina Zeki;Caunca, Michelle R.;Wright, Clinton B.
我们研究了是否更大的抑郁症状与特定领域的认知能力，认知的变化，脑萎缩和亚临床脑血管疾病的MRI标记物在不同的样本中的老年人从北方曼哈顿Study.MethodsData进行了分析，从北方曼哈顿研究，主要是加勒比海西班牙裔，无中风，老年人的前瞻性队列研究。共有1,111名参与者有抑郁症状的基线测量，测量为流行病学中心抑郁量表，MRI标记物和认知功能。流行病学中心抑郁评分>= 16被认为是更严重的抑郁症状的指示。多变量线性和逻辑回归模型被用来检查协会的interests.ResultsAt基线，22%的参与者有更大的抑郁症状。在调整了社会人口统计学、血管危险因素、行为和抗抑郁药物变量的模型中，抑郁症状越严重，基线情景记忆越差（β [95%置信区间] = -0.21 [-0.33 to -0.10]，p = 0.0003）。更大的抑郁症状也与更小的脑实质分数相关（β [95%置信区间] = -0.56 [-1.05 to -0.07]，p = 0.02）和亚临床脑梗死的几率增加（比值比[95%可信区间] = 1.55 [1.00-2.42]，p = 0.05），调整社会人口统计学、行为和血管危险因素变量后。在平均5年的时间里，更严重的抑郁症状与白色高信号体积、海马体积或认知变化无显著相关。结果没有变化时，稳定的逆概率权重，以解决选择性磨损在studyperiod.ConclusionsIn这个样本中的大多数加勒比海西班牙裔，无中风，老年人，更大的抑郁症状与更糟糕的情景记忆，更小的脑容量，和沉默梗死。
ObjectiveWe examined whether greater depressive symptoms were associated with domain-specific cognitive performance, change in cognition, and MRI markers of brain atrophy and subclinical cerebrovascular disease in a diverse sample of older adults from the Northern Manhattan Study.MethodsData were analyzed from the Northern Manhattan Study, a prospective cohort study of mostly Caribbean Hispanic, stroke-free, older adults. A total of 1,111 participants had baseline measures of depressive symptoms, measured as the Center of Epidemiological Studies-Depression Scale, MRI markers, and cognitive function. A Center of Epidemiological Studies-Depression score >= 16 was considered indicative of greater depressive symptoms. Multivariable linear and logistic regression models were used to examine the associations of interest.ResultsAt baseline, 22% of participants had greater depressive symptoms. Greater depressive symptoms were significantly associated with worse baseline episodic memory in models adjusted for sociodemographic, vascular risk factor, behavioral, and antidepressive medication variables (beta [95% confidence interval] = -0.21 [-0.33 to -0.10], p = 0.0003). Greater depressive symptoms were also associated with smaller cerebral parenchymal fraction (beta [95% confidence interval] = -0.56 [-1.05 to -0.07], p = 0.02) and increased odds of subclinical brain infarcts (odds ratio [95% confidence interval] = 1.55 [1.00-2.42], p = 0.05), after adjustment for sociodemographic, behavioral, and vascular risk factor variables. Greater depressive symptoms were not significantly associated with white matter hyperintensity volume, hippocampal volume, or change in cognition over an average of 5 years. Results were unchanged when stabilized inverse probability weights were applied to address selective attrition during the study period.ConclusionsIn this sample of mostly Caribbean Hispanic, stroke-free, older adults, greater depressive symptoms were associated with worse episodic memory, smaller cerebral volume, and silent infarcts.