In-vivo measurements of wall shear stress in human coronary arteries
In-vivo measurements of wall shear stress in human coronary arteries
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DOI：
10.1097/00019501-200009000-00008
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发表时间：
2000-09-01
影响因子：
1.8
通讯作者：
Delafontaine, P
中科院分区：
文献类型：
--
作者：
Doriot, PA;Dorsaz, PA;Delafontaine, P
壁剪切应力（WSS）与动脉硬化密切相关。各种血管和物种的WSS值都是可用的，但人类冠状动脉的完全体内测量尚未有报道。目的测定成年患者静止状态下未病变冠状动脉的WSS。方法用0.036 cm多普勒线（FloWire）记录21例经心导管治疗各种疾病的患者冠状动脉造影正常分叉的三个血管段瞬时最大血流速度的时间平均值（APV），共检查36个分叉。通过三维血管造影技术测定36 × 3横截面积（CSA）。按照Q = 0.5 X APV X CSA计算每个分叉的三个流量Q(1)（流入）、Q(2)、Q(3)。对于每个节段，WSS计算为WSS = 32 eta Q/(pi D-3)（其中血液粘度eta = 3.5 mPa s， D为血管直径）。只有满足方程Q(1)/(Q(2) + Q(3)) = 1的54个流三元组的WSS值较其他18个流三元组保留。结果54个WSS值范围为0.33 ~ 1.24 Pa（平均0.68 Pa， SEM, 0.027 Pa）。它们不依赖于Q （r = 0.07; P = 0.60）和CSA (r = 0.24, P = 0.08)，但第二个关系接近显著性。结论获得的平均WSS值（0.68 Pa）是冠状动脉最优性预测值的一半。它也比许多报道的人颈动脉、肾动脉和股动脉的数值要小。《中华动脉粥样硬化病杂志》（英文版），2004。
Background Wall shear stress (WSS) is closely associated with arteriosclerosis. WSS values for various vessels and species are available, but fully in-vivo measurements in human coronary arteries have not yet been reported.Objective To measure WSS in undiseased coronary arteries of adult patients at rest.Methods We recorded the temporal average value (APV) of the instantaneous maximal blood velocity in the three vessel segments of angiographically normal coronary artery bifurcations in 21 patients undergoing cardiac catheterization to treat various diseases by means of a 0.036 cm Doppler wire (FloWire), In total, 36 bifurcations were examined. The 36 X 3 cross-sectional areas (CSA) were determined by means of a three-dimensional angiographic technique. The three flows, Q(1) (inflow), Q(2), and Q(3) of each bifurcation were calculated according to Q = 0.5 X APV X CSA. For each segment, WSS was calculated as WSS = 32 eta Q/(pi D-3) (where blood viscosity eta = 3.5 mPa s and D is vessel diameter). Only the 54 WSS values obtained from the 18 flow triplets which satisfied the equation Q(1)/(Q(2) + Q(3)) = 1 better than did the 18 other ones were retained. Results The 54 WSS values ranged from 0.33 to 1.24 Pa (mean 0.68 Pa, SEM, 0.027 Pa). They did not depend significantly on Q (r = 0.07; P = 0.60) and the CSA (r = 0.24, P = 0.08) but the second relationship approached significance.Conclusion The obtained mean WSS value (0.68 Pa) is half the value predicted for coronary arteries from optimality principles. It is also smaller than many values reported for human carotid, renal, and femoral arteries. Coron Artery Dis 11:495-502 (C) 2000 Lippincott Williams & Wilkins.