Adipose Tissue Dysregulation in Patients with Metabolic Syndrome
Adipose Tissue Dysregulation in Patients with Metabolic Syndrome
复制标题
DOI：
10.1210/jc.2011-1577
复制
发表时间：
2011-11-01
影响因子：
5.8
通讯作者：
Jialal, Ishwarlal
中科院分区：
文献类型：
--
作者：
Bremer, Andrew A.;Devaraj, Sridevi;Jialal, Ishwarlal
背景：代谢综合征（MetS）与糖尿病和心血管疾病（CVD）的风险增加有关。许多研究小组发现met中炎症循环生物标志物增加。然而，关于这种低度炎症的细胞来源的数据很少。目的：本研究的目的是确定sc脂肪组织（SAT）生物学在未合并糖尿病或心血管疾病的新生MetS中的作用。患者和方法：在知情同意后招募met患者和对照组。采集空腹血，活检获得SAT。结果：炎症和胰岛素抵抗的循环生物标志物、高敏c反应蛋白（hsCRP）、IL-6、IL-1 β、瘦素、血清淀粉样蛋白A和视黄醇结合蛋白-4 （RBP-4）浓度在MetS受试者中显著高于对照组，而脂联素浓度较低。在SAT中，瘦素、RBP-4、CRP、血清淀粉样蛋白A、纤溶酶原激活物抑制剂-1、IL-1、IL-6、IL-8和单核细胞趋化蛋白-1 （MCP-1）水平显著高于对照组。除RBP-4外，这些差异在调整腰围后仍然存在。此外，与对照组相比，巨噬细胞浸润met的SAT数量显著增加，冠状结构数量显著增加。hsCRP与稳态模型评估和SAT MCP-1呈正相关，与脂联素呈负相关。稳态模型评估与纤溶酶原激活物抑制剂-1、RBP-4和SAT MCP-1呈正相关。结论：我们得出了新的观察结果，met的SAT增加了具有基本冠状结构特征的巨噬细胞募集，并有助于细胞炎症的增加，从而产生与胰岛素抵抗和低级别炎症相关的生物标志物水平的增加。这些异常可能导致MetS的进展以及糖尿病和心血管疾病的风险增加。[J] .中华内分泌杂志，2011,31(2):389 - 389。
Context: The metabolic syndrome (MetS) is associated with increased risk of diabetes and cardiovascular disease (CVD). Numerous groups have shown increased circulating biomarkers of inflammation in MetS. However, there are scanty data on the cellular sources contributing to this low-grade inflammation.Objective: The aim of this study was to determine the role of sc adipose tissue (SAT) biology in nascent MetS without concomitant diabetes or CVD.Patients and Methods: Subjects with MetS and controls were recruited after informed consent. Fasting blood was collected, and SAT was obtained by biopsy.Results: Circulating biomarkers of inflammation and insulin resistance, high-sensitivity C-reactive protein (hsCRP), IL-6, IL-1 beta, leptin, serum amyloid A, and retinol-binding protein-4 (RBP-4) concentrations were significantly higher in the MetS subjects than controls, whereas adiponectin concentrations were lower. In SAT, leptin, RBP-4, CRP, serum amyloid A, plasminogen activator inhibitor-1, IL-1, IL-6, IL-8, and monocyte chemotactic protein-1 (MCP-1) levels were significantly higher in MetS than controls. These differences except for RBP-4 persisted after adjusting for waist circumference. In addition, there were significantly increased numbers of macrophages infiltrating the SAT of MetS and increased numbers of crown-like structures compared with controls. hsCRP correlated positively with homeostasis model assessment and SAT MCP-1 and negatively with adiponectin. Homeostasis model assessment correlated positively with plasminogen activator inhibitor-1, RBP-4, and SAT MCP-1.Conclusions: We make the novel observation that SAT of MetS has increased macrophage recruitment with cardinal crown-like structure features and contributes to the increased cellular inflammation that produces increased levels of biomarkers that are correlated with both insulin resistance and low-grade inflammation. These aberrations could contribute to the progression of MetS and the increased risk for diabetes and CVD. (J Clin Endocrinol Metab 96: E1782-E1788, 2011)