Cutaneous tuberculosis of the nose with unusual clinical and histological features leading to delay in diagnosis
Cutaneous tuberculosis of the nose with unusual clinical and histological features leading to delay in diagnosis
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鼻皮肤结核具有异常的临床和组织学特征，导致诊断延误
DOI：
10.1111/j.1365-2133.1976.tb07885.x
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
E. Jones
中科院分区：
文献类型：
--
作者：
A. Warin;E. Jones
其内部结构基本正常。黑素体的自吞噬作用在这些细胞中是常见的，具有膜结合的黑素体聚集体。除了这些黑素体复合物，还有含有线粒体碎片的溶酶体结构以及层状体。“结节”细胞主要是I型，但黑素体和核异常比“周围”细胞更频繁。还发现了一些未分化的II型和III型细胞。这些细胞含有球形黑素体，这些黑素体要么是流产的黑素体，含有一条或两条卷曲的黑素丝，没有交叉条纹，要么是膜结合的细胞器，具有不同电子密度的颗粒状内部基质。恶性雀斑样痣型黑色素瘤的超微结构与浅表扩散型（Pagetoid）和结节型黑色素瘤的超微结构形成鲜明对比，并有所不同。
whose internal structure was essentially normal. Auto-phagocytosis of melanosomes was common in these cells with membrane bounded aggregates of melanosomes. In addition to these melanosomal complexes there were lysosomal structures containing mitochondrial debris as well as lamellated bodies. The 'nodule' cells were mainly Type I, but melanosomal and nuclear abnormalities were more frequent than in the 'surround' cells. There were also a few more undifferentiated Type II and Type III cells to be found. These cells contained spherical melanosomes which were either abortive melanosomes containing one or two coiled melanofilaments with no cross striations or membrane bounded organelles with a granular internal matrix of varying electron density. The ultrastructural findings in lentigo-maligna melanoma sharply contrast with and differ from those of the superficial spreading (Pagetoid) and nodular types of melanoma.