Anti-Inflammatory Mechanisms of Sepsis
Anti-Inflammatory Mechanisms of Sepsis
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DOI：
10.1159/000324024
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Ayala, Alfred
中科院分区：
文献类型：
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作者：
Shubin, Nicholas J.;Monaghan, Sean F.;Ayala, Alfred
在过去的二十年里，人们普遍认为脓毒症有两个炎症阶段，一个是促炎阶段，称为全身炎症反应综合征(SIRS)，另一个是抗炎阶段，称为代偿性抗炎反应综合征(CARS)。考虑到旨在减轻促炎脓毒症反应的治疗干预措施通常都失败了，最近的许多研究都在了解脓毒症患者如何以及为什么表现出免疫抑制特征，败血症免疫抑制的意义可能是什么，以及CARS中是否存在任何治疗靶点。在这里，我们通过讨论目前认为哪些抗炎剂、受体和细胞群对CARS起作用来描述脓毒症免疫抑制/CARS阶段的潜在机制。版权所有(C)2011 S.Karger AG，巴塞尔
Over the past two decades, it has become well accepted that sepsis exhibits two, oftentimes concomitant, inflammatory stages; a pro-inflammatory phase, referred to as the systemic inflammatory response syndrome (SIRS), and an anti-inflammatory phase, called the compensatory anti-inflammatory response syndrome (CARS). Considering that therapeutic interventions designed to attenuate the pro-inflammatory septic response have generally failed, much recent research has gone into understanding how and why septic patients display immunosuppressive characteristics, what the significance of septic immunosuppression may be and if there exists any therapeutic targets within the CARS. Herein, we describe the potential mechanisms of the immunosuppressive/CARS phase of sepsis by discussing what anti-inflammatory agents, receptors and cell populations are currently believed to contribute to CARS. Copyright (C) 2011 S. Karger AG, Basel