Tumor response to arterial embolization hyperthermia and direct injection hyperthermia in a rabbit liver tumor model
Tumor response to arterial embolization hyperthermia and direct injection hyperthermia in a rabbit liver tumor model
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DOI：
10.1002/jso.10118
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发表时间：
2002-07-01
影响因子：
2.5
通讯作者：
Gray, BN
中科院分区：
文献类型：
--
作者：
Moroz, P;Jones, SK;Gray, BN
背景和目的：在小动物模型中，用铁磁性颗粒动脉栓塞或直接注射肝脏肿瘤是可能的，这种颗粒暴露在交变磁场中会产生滞后加热。本研究的目的是比较动脉栓塞热疗(AEH)和直接注射热疗(DIH)对肝肿瘤的反应。方法：10只实验性肝肿瘤兔用AEH治疗，另10只兔用DIH治疗。两组肿瘤均加热至43℃~50℃20分钟。结果：AEH组肿瘤体积缩小50%~94%(P=0.005)，平均质量(中位数1.73gm)显著低于未治疗对照组(中位数8.01gm，n=20；P<；0.001)。接受治疗的肿瘤中有三个是完全坏死的，其余的至少80%是坏死的。在接受DIH治疗的10个肿瘤中，有9个肿瘤体积增加了至少143%(P=0.01)，其平均质量(中位数5.68gm)与未治疗的对照肿瘤没有显著差异(P=0.56)。结论：在中等温度下，AEH比DIH更有效。这可能是因为使用动脉栓塞术可以获得更广泛的颗粒分布，从而导致对肿瘤的更广泛和完整的治疗。(C)2002年Wiley-Liss，Inc.
Background and Objectives: It is possible to arterially embolize or directly inject liver tumors in small animal models with ferromagnetic particles that generate hysteretic heating on exposure to an alternating magnetic field. The objective of this study was to compare the response of liver tumors to arterial embolization hyperthermia (AEH) and direct injection hyperthermia (DIH).Methods: Ten rabbits containing experimental hepatic tumors were treated with AEH, and a second group of ten rabbits were treated with DIH. The tumors of both groups were heated to 43degrees to 50degreesC for 20 minutes. Tumor response, which was determined by measuring change in tumor volume and by comparison of tumor mass after treatment with the mass of untreated control tumors of the same age, was assessed 14 days after treatment.Results: All tumors treated with AEH decreased in volume by 50% to 94% (P = 0.005), and their average mass (median 1.73 gm) was significantly less than that of untreated control tumors (median 8.01 gm, n = 20; P < 0.001). Three of the treated tumors were completely necrotic, while the remainder were at least 80% necrotic. Nine of the ten tumors treated with DIH increased in volume by at least 143% (P = 0.01), and their average mass (median 5.68 gm) was not significantly different from that of the untreated control tumors (P = 0.56).Conclusion: These results indicate that AEH is more effective than DIH at moderately elevated temperatures. This is probably because the more widespread particle distribution that can be achieved using arterial embolization results in more extensive and complete treatment of the tumor. (C) 2002 Wiley-Liss, Inc.