Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects
Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects
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深部和浅表实验诱发的急性疼痛对人体皮肤交感神经活动的影响
DOI：
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发表时间：
2009
影响因子：
2
通讯作者：
V. Macefield
中科院分区：
文献类型：
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作者：
A. Burton;I. Birznieks;J. Spaak;L. Henderson;V. Macefield
有证据表明，在实验动物中，深部疼痛和浅表疼痛对皮肤交感神经活动产生不同的影响。从清醒受试者的腓总神经记录皮肤交感神经活动(SSNA)，并在意想不到的时间向胫前肌注射0.5毫升高渗盐水(引起深度、钝痛)或向其上的皮肤注射0.2毫升(引起剧烈灼痛)。深部和浅部疼痛均导致SSNA在注射后即刻和肌肉和皮肤疼痛开始之前增加(S的肌肉和皮肤疼痛分别为10.1%±52.4%和15.3%±55.3%；肌肉与皮肤分别为10.1%±22.4%和15.3%±55.3%；肌肉与皮肤分别为10.1%±2.4%和15.3%±55.3%)。SSNA的增加是短暂的(104.2±13.4比81.8±11.7比S；肌肉与皮肤疼痛)，并且没有遵循肌肉和皮肤疼痛的特征。在肌肉内和皮下注射高渗盐水后，汗液都会释放。虽然肌肉或皮肤疼痛总是会导致皮肤血流量的变化和汗液释放的增加，但女性的皮肤血流量增加，男性的皮肤血流量减少。我们的结论是，急性肌肉和皮肤疼痛都会导致SSNA增加，汗液释放和皮肤血流量的性别相关性变化。
There is evidence in experimental animals that deep and superficial pain exert differential effects on cutaneous sympathetic activity. Skin sympathetic nerve activity (SSNA) was recorded from the common peroneal nerve of awake human subjects and injections of 0.5 ml hypertonic saline was made into the tibialis anterior muscle (causing a deep, dull ache) or 0.2 ml into the overlying skin (causing a sharp burning pain) at unexpected times. Both deep and superficial pain caused increases in SSNA immediately on injection and preceding the onset of pain for both muscle and skin pain (10.1 ± 2.4 vs. 15.3 ± 5.3 s; muscle versus skin, respectively). SSNA increases were short lasting (104.2 ± 13.4 vs. 81.8 ± 11.7 s; muscle versus skin pain) and did not follow muscle and skin pain profiles. Sweat release occurred following both intramuscular and subcutaneous injections of hypertonic saline. While muscle or skin pain invariably caused changes in skin blood flow as well as increases in sweat release, skin blood flow increased in females and decreased in males. We conclude that both acute muscle and skin pain cause an increase in SSNA, sweat release and gender-dependent changes in skin blood flow.
GABA 在动眼神经系统中的通路和功能。
影响因子：
--
作者：
Spencer,RF;Wang,SF;Baker,R
通讯作者：
Baker,R