Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins.
Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins.
复制标题
视网膜的无创功能成像揭示了视网膜外层和血流动力学内在光学信号的起源。
DOI：
10.1007/s10384-009-0687-2
复制
发表时间：
2009
影响因子：
2.4
通讯作者：
Soliz,Peter
中科院分区：
文献类型：
--
作者：
Ts'o,Daniel;Schallek,Jesse;Kwon,Young;Kardon,Randy;Abramoff,Michael;Soliz,Peter
We have adapted intrinsic signal optical imaging of neural activity to the noninvasive functional imaging of the retina. Results to date demonstrate the feasibility and potential of this new method of functional assessment of the retina. In response to visual stimuli, we have imaged reflectance changes in the retina that are robust and spatially colocalized to the sites of stimulation. However, the technique is in its infancy and many questions as to the underlying mechanisms remain. In particular, the source and nature of the activity-dependent intrinsic optical signals in the retina need to be characterized and their anatomic origins determined. The studies described here begin to address these issues. The evidence indicates that the imaged signals are driven by the outer retinal layers and have a dominant hemodynamic component.
