The role of Fc-FcγR interactions in IgG-mediated microbial neutralization.
The role of Fc-FcγR interactions in IgG-mediated microbial neutralization.
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DOI：
10.1084/jem.20151267
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发表时间：
2015-08-24
期刊：
影响因子：
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通讯作者：
Ravetch JV
中科院分区：
文献类型：
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作者：
Bournazos S;DiLillo DJ;Ravetch JV
Bournazos，DiLillo和Ravetch讨论了Fc受体的生物学及其在感染和治疗过程中对保护性抗体反应的效应子功能的贡献。抗体是双功能分子，含有介导结合特异性的可变Fab结构域和将抗体包被的靶标与介导效应子功能的Fcγ R表达细胞连接起来的恒定Fc结构域。尽管抗体介导的微生物中和的传统机制在很大程度上被认为是Fab-抗原相互作用的结果，但最近的研究表明，抗体募集表达Fcγ R的效应细胞是抗体介导的感染保护的主要体内机制。在这篇文章中，我们回顾了FcγR的生物学，比较哺乳动物FcγR家族，并总结了最近的证据表明，Fc-Fc γR相互作用在体内保护免受感染中起着至关重要的作用。
Bournazos, DiLillo, and Ravetch discuss the biology of Fc receptors and their contribution to the effector function of protective antibody responses during infections and in therapeutics. Antibodies are bifunctional molecules, containing a variable Fab domain that mediates binding specificity and a constant Fc domain that bridges antibody-coated targets with FcγR-expressing cells that mediate effector functions. Although traditional mechanisms of antibody-mediated neutralization of microbes have been largely thought to result from Fab–antigen interactions, recent studies suggest that recruitment of FcγR-expressing effector cells by antibodies is a major in vivo mechanism of antibody-mediated protection from infection. In this article, we review FcγR biology, compare mammalian FcγR families, and summarize recent evidence demonstrating the crucial role that Fc–FcγR interactions play during in vivo protection from infection.