Recent improvements of the ProDom database of protein domain families
Recent improvements of the ProDom database of protein domain families
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DOI：
10.1093/nar/27.1.263
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发表时间：
1999-01-01
影响因子：
14.9
通讯作者：
Kahn, D
中科院分区：
文献类型：
--
作者：
Corpet, F;Gouzy, J;Kahn, D
ProDom数据库包含通过自动序列比较从SWISS-PROT数据库生成的蛋白质结构域家族。目前的版本是建立了一个新的改进程序的基础上递归PSI-BLAST同源性搜索。可以在万维网上搜索ProDom，借助用户友好的图形界面（http：//www.toulouse.inra.fr/prodom.html）研究已知家族或新蛋白质的结构域排列。最近对ProDom服务器的改进包括：SRS序列检索系统下的ProDom查询;与PredictProtein服务器的链接;系统发生树和浓缩的多重比对，以更好地表示大域家族，具有放大和缩小功能。此外，还建立了一个类似的服务器，以显示应用于17个完整微生物基因组的全基因组域分析结果（http：//www.toulouse.inra.fr/prodomCG.html）。
The ProDom database contains protein domain families generated from the SWISS-PROT database by automated sequence comparisons. The current version was built with a new improved procedure based on recursive PSI-BLAST homology searches. ProDom can be searched on the World Wide Web to study domain arrangements within either known families or new proteins, with the help of a user-friendly graphical interface (http://www.toulouse.inra.fr/prodom.html). Recent improvements to the ProDom server include: ProDom queries under the SRS Sequence Retrieval System; links to the PredictProtein server; phylogenetic trees and condensed multiple alignments for a better representation of large domain families, with zooming in and out capabilities. In addition, a similar server was set up to display the outcome of whole genome domain analysis as applied to 17 completed microbial genomes (http://www.toulouse.inra.fr/prodomCG.html).