Involvement of the axially condensed tail bud mesenchyme in normal and abnormal human posterior neural tube development
Involvement of the axially condensed tail bud mesenchyme in normal and abnormal human posterior neural tube development
复制标题
轴向浓缩尾芽间充质参与正常和异常人后神经管发育
DOI：
10.1111/j.1741-4520.2007.00178.x
复制
发表时间：
2008
影响因子：
1.3
通讯作者：
K. Shiota
中科院分区：
文献类型：
--
作者：
H. Saitsu;K. Shiota
摘要 人类胚胎中后神经管（PNT）的发育是一个复杂的过程，涉及初级神经管和次级神经管。应了解人类PNT的正常发育以阐明脊髓神经管缺陷的发病机制，但之前的报道存在一些差异。我们对后神经孔闭合阶段的20个人类胚胎进行组织学检查，发现发育中的PNT可分为三个部分：（1）最喙区，对应于初级神经管的后部； (2)初级和次级神经管的连接区； (3)从神经索出现的尾部区域。在交界区，轴向浓缩的间充质（AM）介入神经板/管和脊索之间。 AM 似乎并入初级神经管的最腹侧部分，并且在 AM 中没有观察到空腔。有趣的是，我们发现了三例患有腰骶脊髓劈裂的人类胚胎，其中开放的初级神经管和闭合的次级神经管在背腹侧重叠。开放和封闭的神经管似乎分别是初级神经管和 AM 衍生的次级神经管的一部分。因此，这些发现表明，在患有腰骶脊髓劈裂的胚胎中，AM可能不会并入初级神经管的腹侧部分，而是异常分化为含有空腔的次级神经管，导致初级和次级神经管的背腹重叠。这些发现表明，人类胚胎中的AM在人类后神经管的正常和异常发育中发挥着一定作用。
ABSTRACT Development of the posterior neural tube (PNT) in human embryos is a complicated process which involves both primary and secondary neurulation. Normal development of the human PNT should be understood to elucidate the pathogenesis of spinal neural tube defects, but there have been some discrepancies among previous reports. We examined histologically 20 human embryos around the stage of the posterior neuropore closure and found that the developing PNT can be divided into three parts: (1) the most rostral region which corresponds to the posterior part of the primary neural tube; (2) the junctional region of the primary and secondary neural tubes; and (3) the caudal region which emerges from the neural cord. In the junctional region, the axially condensed mesenchyme (AM) intervened between the neural plate/tube and the notochord. The AM appeared to be incorporated into the most ventral part of the primary neural tube, and no cavity was observed in the AM. Interestingly, we found three cases of human embryos with lumbosacral myeloschisis in which the open primary neural tube and the closed secondary neural tube overlapped dorso‐ventrally. The open and closed neural tubes appeared to be part of the primary and the AM‐derived secondary neural tubes, respectively. Thus, these findings suggest that in embryos with lumbosacral myeloschisis, the AM may not be incorporated into the ventral part of the primary neural tube but aberrantly differentiate into the secondary neural tube containing cavities, leading to dorso‐ventral overlapping of the primary and secondary neural tubes. These findings suggest that the AM in human embryos plays some role in normal and abnormal development of the human posterior neural tube.
DOI：
10.1002/bdra.20183
发表时间：
2005-11-01
影响因子：
--
作者：
Deak, KL;Dickerson, ME;Speer, MC
通讯作者：
Speer, MC