Histological evidence for neuroprotective action of nebracetam on ischemic neuronal injury in the hippocampus of stroke-prone spontaneously hypertensive rats.
Histological evidence for neuroprotective action of nebracetam on ischemic neuronal injury in the hippocampus of stroke-prone spontaneously hypertensive rats.
复制标题
奈布拉西坦对易发生中风的自发性高血压大鼠海马缺血性神经元损伤的神经保护作用的组织学证据。
DOI：
10.1254/jjp.67.91
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
K. Taniyama
中科院分区：
文献类型：
--
作者：
M. Nakashima;Y. Kataoka;K. Yamashita;M. Kohzuma;M. Ichikawa;M. Niwa;Y. Kohno;K. Taniyama
The protective effect of nebracetam on ischemic neuronal damage was histologically examined in the pyramidal cell layer of the hippocampal CA1 subfield 7 days after operation using stroke-prone spontaneously hypertensive rats (SHRSP) subjected to 10-min bilateral carotid occlusion. Nebracetam (50 and 100 mg/kg), given orally 10 min after reperfusion, dose-dependently protected against ischemic delayed neuronal damage in the SHRSP with occlusion; however, the blood pressure remained unchanged following nebracetam administration. These findings further support the notion that nebracetam protects against ischemic delayed neuronal cell death in the hippocampus.
