ModelFinder: fast model selection for accurate phylogenetic estimates.
ModelFinder: fast model selection for accurate phylogenetic estimates.
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DOI：
10.1038/nmeth.4285
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发表时间：
2017-06
期刊：
影响因子：
48
通讯作者：
Jermiin LS
中科院分区：
文献类型：
--
作者：
Kalyaanamoorthy S;Minh BQ;Wong TKF;von Haeseler A;Jermiin LS
基于模型的分子系统发育在基因组数据比较中起着重要作用，而模型选择是所有这些分析的关键步骤。我们提出了ModelFinder，一种快速的模型选择方法，大大提高了系统发育估计的准确性。这种改进是通过合并一个在此上下文中没有考虑到的跨站点的速率异质性模型，以及允许同时搜索模型空间和树空间来实现的。
Model-based molecular phylogenetics plays an important role in comparisons of genomic data, and model selection is a key step in all such analyses. We present ModelFinder, a fast model-selection method that greatly improves the accuracy of phylogenetic estimates. The improvement is achieved by incorporating a model of rate-heterogeneity across sites not previously considered in this context, and by allowing concurrent searches of model-space and tree-space.