The prevalence of thalassemia in mainland China: evidence from epidemiological surveys.
The prevalence of thalassemia in mainland China: evidence from epidemiological surveys.
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中国大陆地中海贫血患病率：流行病学调查证据
DOI：
10.1038/s41598-017-00967-2
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发表时间：
2017-04-19
影响因子：
4.6
通讯作者：
He Y
中科院分区：
文献类型：
--
作者：
Lai K;Huang G;Su L;He Y
中国大陆缺乏关于地中海贫血流行病学和患病率的综合数据。为了评估地中海贫血的患病率，我们进行了一项荟萃分析，包括1981年至2015年发表的16篇文章。α-地中海贫血、β-地中海贫血和α + β-地中海贫血的总患病率分别为7.88%、2.21%和0.48%。中国大陆地区地中海贫血流行趋势不稳定；基于地理信息系统（GIS）的患病率图显示，中国地中海贫血的地理分布以南方最高，自南向北递减。此外，最常见的α珠蛋白和β珠蛋白基因突变分别是-SEA和CD41/42。目前的研究提供了有关流行病学和干预措施的宝贵信息，并支持公共卫生预防方案的规划、实施和管理。
Comprehensive data regarding the epidemiology and prevalence of thalassemia in mainland China are lacking. To assess the prevalence of thalassemia, we performed a meta-analysis including 16 articles published from 1981 to 2015. The overall prevalence of α-thalassemia, β-thalassemia and α + β-thalassemia was 7.88%, 2.21% and 0.48%, respectively. Trends in thalassemia prevalence in mainland China were not steady; a prevalence map based on a geographic information system (GIS) showed that the geographic distribution of thalassemia was highest in the south of China and decreased from south to north. Additionally, the most common α- and β-globin gene mutation was --SEA and CD41/42, respectively. The current study provides valuable information regarding epidemiology and intervention and supports the planning, implementation and management of prevention programmes for public health.