Circadian Disruption And Surgical Recovery
Circadian Disruption And Surgical Recovery
复制标题
昼夜节律紊乱和手术恢复
DOI：
10.1097/00006199-198805000-00010
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发表时间：
1988
期刊：
影响因子：
2.5
通讯作者：
J. Mack
中科院分区：
文献类型：
--
作者：
L. Farr;C. Campbell;J. Mack
通过体温和自发活动测量手术后大鼠的昼夜节律，并通过活动水平测量术后恢复。随机选择8只Sprague-Dawley大鼠，在全身麻醉下植入无线电温度传感器。定时控制的盒式录音机以预定的时间间隔记录体温。为了监测活动，将大鼠置于配备有红外敏感运动活动监测器的单独代谢笼中。每小时对温度进行采样。连续测量活性并每15分钟求和以进行取样。在手术前开始测量，并在手术后12至20天继续测量，这取决于动物何时恢复其典型的节律模式。温度和活动节律被改变，并以类似于先前在人类中发现的方式与外部线索脱钩。动物在恢复到术前活动水平方面表现出个体差异。手术后6天，大鼠经历了第二个节律紊乱和活动减少的时期。具有最大活动相移的大鼠需要最长时间才能恢复到手术前的活动水平。这表明，手术后昼夜节律改变的程度与恢复和节律性再诱导所需的时间呈正相关。
Circadian rhythms were investigated in rats following surgery, as measured by body temperature and locomotor activity, and postoperative recovery was measured by activity level. Eight randomly selected Sprague-Dawley rats were implanted with radio temperature-transmitters under general anestheisa. Timer-controlled cassette recorders recorded body temperature at predetermined intervals. To monitor activity, the rats were placed in individual metabolic cages equipped with infrared-sensitive locomotor activity monitors. Temperature was sampled hourly. Activity was measured continuously and summed every 15 minutes for sampling. Measurement was begun before surgery and continued from 12 to 20 days following surgery, depending on when the animals regained their typical rhythmic patterns. Temperature and activity rhythms were altered and uncoupled from external cues in a manner similar to that previously found in humans. The animals demonstrated individual variation in their return to presurgical activity levels. Six days after surgery, the rats experienced a second period of disrhythmic and decreased activity. Rats with the greatest activity phase-shifts took longest to return to presurgical activity levels. This suggests that the degree of circadian alteration following surgery is positively related to the time required for recovery and reentrainment of rhythmicity.