Lymphocytic bronchitis unrelated to acute graft-versus-host disease in canine marrow graft recipients.
Lymphocytic bronchitis unrelated to acute graft-versus-host disease in canine marrow graft recipients.
复制标题
犬骨髓移植受者中与急性移植物抗宿主病无关的淋巴细胞性支气管炎。
DOI：
10.1097/00007890-198403000-00003
复制
发表时间：
1984
期刊：
影响因子：
6.2
通讯作者：
Storb,R
中科院分区：
文献类型：
--
作者：
O'Brien,KD;Hackman,RC;Sale,GE;Prentice,R;Deeg,J;Thomas,ED;Storb,R
我们回顾了71只狗的编码尸检材料，其中46只接受同种异体骨髓移植，25只接受自体骨髓移植，以评估淋巴细胞性支气管炎与严重急性移植物抗宿主病（GVHD）相关的假设。我们发现淋巴细胞性支气管炎与严重急性GVHD之间无显著相关性（P < 0.16）。使用二元回归模型校正了可能的混杂关系，我们未能显示淋巴细胞性支气管炎和急性GVHD之间的相关性。淋巴细胞性支气管炎与急性细菌性肺炎无相关性（P < 0.32）。最后，自体移植犬存在淋巴细胞性支气管炎，尸检时患病率与同种异体移植犬无显著差异（P >.32）。我们得出结论，这个犬模型中的淋巴细胞性支气管炎代表非特异性炎症，而不是急性肺GVHD。
We reviewed coded autopsy material from 71 dogs, 46 receiving allogeneic and 25 receiving autologous bone marrow transplants, to evaluate the hypothesis that lymphocytic bronchitis is associated with severe acute graft-versus-host disease (GVHD). We found no significant correlation between the presence of lymphocytic bronchitis and severe acute GVHD (P> 0.16). Using a binary regresson model that corrected for possible confounding relationships, we failed to show a correlation between lymphocytic bronchitis and acute GVHD of each of the 3 classically affected organ systems. Also, no correlation was found between lymphocytic bronchitis and acute bacterial pneumonia (P> 0.32). Finally, lymphocytic bronchitis was present in autografted dogs with a prevalence at autopsy not significantly different from that of allografted dogs (P> 0.32). We conclude that lymphocytic bronchitis in this canine model represents nonspecific inflammation rather than acute pulmonary GVHD.