Circadian health differs between boys and girls as assessed by non-invasive tools in school-aged children
Circadian health differs between boys and girls as assessed by non-invasive tools in school-aged children
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DOI：
10.1016/j.clnu.2018.03.001
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发表时间：
2019-04-01
影响因子：
6.3
通讯作者：
Garaulet, Marta
中科院分区：
文献类型：
--
作者：
Maria Barraco, Gloria;Martinez-Lozano, Nuria;Garaulet, Marta
Background & aims: Assessment of circadian health is confined to adults. However, understanding circadian status of school-aged children is necessary due to its health implications. The aim was to develop 1) a protocol to assess circadian function in school-aged children by combining the best non-invasive tools previously validated in adults; 2) a score to capture circadian function in children including food timing. This protocol will allow to explore gender differences and to compare the circadian function of school-aged children with adults from the same Mediterranean area.Methods: Healthy children (8-12 y) from 3 schools in a Mediterranean area of Spain were recruited (n = 248; 125 males and 123 females). Several non-invasive tools were used: a) 7-day-diaries of food timing and food intake, physical-activity and sleep, b) Munich-chronotype-self-reported-questionnaire; c) cortisol and melatonin saliva determinations; d) 7-day-rhythms of wrist temperature (T), activity (A), position (P) and the integrative variable TAP e) 7-day-light exposure.Results: We have constructed the first school-aged children population for the assessment of circadian function (ONTIME-Jr) and a new circadian score has been developed. Among circadian-related measures, TAP was the most suitable and reliable to determine circadian system characteristics. Circadian function was better in girls than in boys [circadian score (AU) Mean +/- SD (girls, 1216 +/- 153 vs. 1159 +/- 173 boys, P = 0.012)], and also in school-aged children than in adults from the same Mediterranean area (Circadian-Function-Index: children 0.47 +/- 0.06 vs. adults 0.45 +/- 0.06 P = 0.001).Conclusions: A new protocol, including TAP and food timing, demonstrated to be reliable in assessing circadian function in children. These non-invasive techniques provide the wherewithal for paediatricians to assess circadian function in clinical practice. (C) 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
