Skin anti-inflammatory activity of rose petal extract (Rosa gallica) through reduction of MAPK signaling pathway
Skin anti-inflammatory activity of rose petal extract (Rosa gallica) through reduction of MAPK signaling pathway
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DOI：
10.1002/fsn3.870
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发表时间：
2018-11-01
影响因子：
3.9
通讯作者：
Lim, Tae-Gyu
中科院分区：
文献类型：
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作者：
Lee, Myung-hee;Nam, Tae Gyu;Lim, Tae-Gyu
本研究旨在探讨玫瑰花瓣提取物（RPE）的皮肤抗炎活性及其机制。近年来，由于其生物活性，如抑制肾炎和痔疮，花卉已被视为膳食资源。蔷薇属植物发挥各种生物功能，包括抗氧化和抗微生物活性。在此，我们证实了RPE在太阳紫外线（sUV）暴露后的皮肤抗炎活性。RPE降低sUV诱导的考克斯-2表达以及几种细胞因子的表达。与细胞因子产生相关的MKK 4-JNK、MEK-ERK和MKK 3-p38信号通路的激活也通过RPE处理减弱。我们假设这些RPE诱导的变化是因为其抗氧化活性，因为RPE显示激烈的自由基清除和氧自由基吸收能力（ORAC）。RPE中花青素、多酚类物质和黄酮类物质含量较高。因此，这些结果表明RPE的皮肤抗炎活性是由于抗氧化活性。
The aim of this study was to investigate the skin anti-inflammatory activity of rose petal extract (RPE) and the mechanisms underlying this phenomenon. Recently, flowers have been considered as dietary resources owing to their biological activities, such as inhibition of nephritis and hemorrhoids. The Rosa plant exerts various biological functions, including antioxidant and anti-microbiological activities. Herein, we confirmed the skin anti-inflammatory activity of RPE upon solar UV (sUV) exposure. RPE reduced sUV-induced COX-2 expression as well as expressions of several cytokines. Activation of MKK4-JNK, MEK-ERK, and MKK3-p38 signaling pathways, which are associated with cytokine production, was also attenuated by RPE treatment. We hypothesized these RPE-induced changes are because of its antioxidant activity, because RPE displayed drastic radical scavenging and oxygen radical absorbance capacity (ORAC). Furthermore, high anthocyanins, polyphenols, and flavonoids contents were found in RPE. Hence, these results indicated the skin anti-inflammatory activity of RPE is because of antioxidant activity.