Paving the Road for Modern Particle Therapy - What Can We Learn from the Experience Gained with Fast Neutron Therapy in Munich?
Paving the Road for Modern Particle Therapy - What Can We Learn from the Experience Gained with Fast Neutron Therapy in Munich?
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DOI：
10.3389/fonc.2015.00262
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发表时间：
2015
影响因子：
4.7
通讯作者：
Combs SE
中科院分区：
文献类型：
--
作者：
Specht HM;Neff T;Reuschel W;Wagner FM;Kampfer S;Wilkens JJ;Petry W;Combs SE
虽然中子治疗在70年代和80年代是一个非常热门的话题，但今天只有少数几个设施提供快中子治疗（FNT）。然而，到今天为止，有30，000多名患者接受了中子治疗。对于某些适应症，如唾液腺肿瘤和恶性黑色素瘤，有临床证据表明，与单独的光子治疗相比，加入FNT导致上级局部控制。从1985年到2000年，FNT可在慕尼黑的反应堆中子治疗（Reactor Neutron Therapy，简称NST）设施中使用。2007年，在改进的治疗条件下，新的研究反应堆FRM II继续对患者进行治疗，今天它仍然可以作为个人治疗选择提供给选定的患者。随着人们对高线性能量转移（LET）治疗的兴趣日益浓厚，新的强子治疗中心在地球仪周围出现，中子治疗产生的临床数据可能有助于开发生物驱动的治疗计划算法。此外，FNT可能会经历其作为现代免疫疗法的组合伙伴的复兴。
While neutron therapy was a highly topical subject in the 70s and 80s, today there are only a few remaining facilities offering fast neutron therapy (FNT). Nevertheless, up to today more than 30,000 patients were treated with neutron therapy. For some indications like salivary gland tumors and malignant melanoma, there is clinical evidence that the addition of FNT leads to superior local control compared to photon treatment alone. FNT was available in Munich from 1985 until 2000 at the Reactor Neutron Therapy (RENT) facility. Patient treatment continued at the new research reactor FRM II in 2007 under improved treatment conditions, and today it can still be offered to selected patients as an individual treatment option. As there is a growing interest in high-linear energy transfer (LET) therapy with new hadron therapy centers emerging around the globe, the clinical data generated by neutron therapy might help to develop biologically driven treatment planning algorithms. Also FNT might experience its resurgence as a combinational partner of modern immunotherapies.