Drosophila olfaction: past, present and future.

Drosophila olfaction: past, present and future.
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DOI:
10.1098/rspb.2022.2054
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发表时间:
2022-12-21
影响因子:
4.7
通讯作者:
Benton, Richard
Benton, Richard
中科院分区:
生物学1区
文献类型:
--
作者:
Benton, Richard

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在大自然的众多奇观中,果蝇的嗅觉乍一看似乎是深奥的。然而,一个多世纪以来,这种昆虫的鼻子一直是一个非凡的系统,用于探索动物行为、生态学和进化、神经科学、生理学和分子遗传学的问题。所获得的见解与我们理解脊椎动物的感觉生物学有关,包括人类和其他昆虫物种,包括那些对人类健康有害的物种。在这里,我概述了我们对黑腹果蝇嗅觉的现有知识,从分子到行为,重点是研究的历史动机和说明技术创新如何使进步成为可能。我还强调了一些紧迫和长期的问题。
Among the many wonders of nature, the sense of smell of the fly Drosophila melanogaster might seem, at first glance, of esoteric interest. Nevertheless, for over a century, the ‘nose’ of this insect has been an extraordinary system to explore questions in animal behaviour, ecology and evolution, neuroscience, physiology and molecular genetics. The insights gained are relevant for our understanding of the sensory biology of vertebrates, including humans, and other insect species, encompassing those detrimental to human health. Here, I present an overview of our current knowledge of D. melanogaster olfaction, from molecules to behaviours, with an emphasis on the historical motivations of studies and illustration of how technical innovations have enabled advances. I also highlight some of the pressing and long-term questions.
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