Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity
Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity
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DOI：
10.1016/s0142-9612(01)00095-3
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发表时间：
2002-01-01
期刊：
影响因子：
14
通讯作者：
Quinn, JB
中科院分区：
文献类型：
--
作者：
Xu, HHK;Quinn, JB
磷酸钙水泥 (CPC) 可形成羟基磷灰石，已用于医疗和牙科手术。然而，CPC 的脆性和低强度限制了其在许多受力部位、无支撑缺损或薄骨重建中的使用。最近的研究将纤维加入到 CPC 中以提高其强度。在本研究中，采用了一种新颖的方法将增强材料与大孔隙相结合：将大直径可吸收纤维纳入 CPC 中以提供短期强度。然后溶解形成大孔。适合骨长入。将两种直径为322μm的可吸收纤维与CPC混合至纤维体积分数为25%。将固定好的试件在37℃的生理盐水中浸泡1、7、14、28和56 d，然后进行三点弯曲试验。 SEM 用于检查裂纹纤维相互作用。 CPC复合材料的弯曲强度是未增强CPC的3倍，断裂功（韧性）接近100倍，大于未增强的CPC。根据纤维溶解速率，强度和韧性可在浸泡 2-4 周后保持不变。纤维溶解后，CPC 复合材料中观察到大孔或通道。总之，掺入大直径可吸收纤维可以在组织再生发生时实现 CPC 所需的短期强度和抗断裂性，然后在纤维溶解时形成适合血管向内生长的大孔。加固机制似乎是裂纹桥接和纤维拔出； CPC基体的机械性能也影响复合材料性能。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
Calcium phosphate cement (CPC) sets to form hydroxyapatite and has been used in medical and dental procedures. However, the brittleness and low strength of CPC prohibit its use in many stress-bearing locations, unsupported defects, or reconstruction of thin bones. Recent studies incorporated fibers into CPC to improve its strength. In the present study, a novel methodology was used to combine the reinforcement with macroporosity: large-diameter resorbable fibers were incorporated into CPC to provide short-term strength. then dissolved to create macropores. suitable for bone ingrowth. Two types of resorbable fibers with 322 mum diameters were mixed with CPC to a fiber volume fraction of 25%. The set specimens were immersed in saline at 37 degreesC for 1, 7. 14, 28 and 56 d, and were then tested in three-point flexure. SEM was used to examine crack-fiber interactions. CPC composite achieved a flexural strength 3 times, and work-of-fracture (toughness) nearly 100 times, greater than unreinforced CPC. The strength and toughness were maintained for 2-4 weeks of immersion, depending on fiber dissolution rate. Macropores or channels were observed in CPC composite after fiber dissolution. In conclusion, incorporating large-diameter resorbable fibers can achieve the needed short-term strength and fracture resistance for CPC while tissue regeneration is occurring, then create macropores suitable for vascular ingrowth when the fibers are dissolved. The reinforcement mechanisms appeared to be crack bridging and fiber pullout; the mechanical properties of the CPC matrix also affected the composite properties. (C) 2001 Elsevier Science Ltd. All rights reserved.