Pain perception in patients with hidradenitis suppurativa
Pain perception in patients with hidradenitis suppurativa
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DOI：
10.1111/bjd.17935
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发表时间：
2020-01-01
影响因子：
10.3
通讯作者：
Jemec, G. B.
中科院分区：
文献类型：
--
作者：
Nielsen, R. M.;Andersen, P. Lindso;Jemec, G. B.
疼痛是化脓性汗腺炎（HS）的一个突出症状，并已被定义为该疾病核心结局集中的一个领域。疼痛的质量和强度的影响，抑郁和焦虑，这两者都与HS.Objectives描述HS相关的疼痛定量和定性，并探讨如何疾病的严重程度，抑郁和焦虑与自我报告的疼痛quality.Methods疼痛感知进行了调查，使用麦吉尔疼痛问卷。抑郁和焦虑的症状进行了检查，使用医院焦虑和抑郁量表。统计分析调查了严重疾病患者和抑郁/焦虑患者的选择字数（NWC）和疼痛评分指数等级[PRI（R）]的差异。结果在门诊（2017年10月至2018年3月）共招募了138例HS患者。患者的中位NWC为11.5，PRI（R）为59.0%。最常见的描述是“射击”（83%），“发痒”（79%）和“致盲”（75%）。患有抑郁或焦虑的患者的PRI（R）明显更高[抑郁65% vs非抑郁57%（P = 0.015）;焦虑65% vs非焦虑57%（P = 0.004）]。3个或3个以上HS区域受累的患者NWC显著高于少于3个HS区域受累的患者（13 vs.8; P = 0.048）。结论HS相关疼痛包括伤害性疼痛和神经病理性疼痛，疼痛感觉受疾病严重程度、焦虑和抑郁的影响。多模式疼痛管理策略可能是最合适的;然而，需要更详细的研究来确定疼痛管理的建议。
Background Pain is a prominent symptom of hidradenitis suppurativa (HS) and has been defined as a domain in the Core Outcome Set for the disease. Quality and intensity of pain is influenced by depression and anxiety, both of which are associated with HS.Objectives To describe HS-related pain quantitatively and qualitatively; and to investigate how disease severity, depression and anxiety correlate with self-reported pain quality.Methods Pain perception was investigated using the McGill Pain Questionnaire. Symptoms of depression and anxiety were examined using the Hospital Anxiety and Depression Scale. Statistical analyses investigated differences in number of words chosen (NWC) and pain-rating index rank [PRI(R)] in patients with severe disease and in patients with depression/anxiety.Results A total of 138 patients with HS were recruited in an outpatient clinic (October 2017-March 2018). Patients presented a median NWC of 11.5 and a PRI(R) of 59.0%. Most common descriptors were 'shooting' (83%), 'itchy' (79%) and 'blinding' (75%). Patients with depression or anxiety presented significantly higher PRI(R)s [depressed 65% vs. non-depressed 57% (P = 0.015); anxious 65% vs. nonanxious 57% (P = 0.004)]. Patients with involvement of three or more HS regions vs. those with fewer than three involved regions exhibited a significantly higher NWC (13 vs. 8; P = 0.048).Conclusions HS-related pain includes nociceptive and neuropathic pain, and perception appears to be influenced by disease severity, anxiety and depression. A multimodal pain management strategy may be the most appropriate; however, more detailed studies are necessary to define recommendations on pain management.