TOPICAL TREATMENT OF AMERICAN CUTANEOUS LEISHMANIASIS WITH PARAMOMYCIN AND METHYLBENZETHONIUM CHLORIDE - A CLINICAL-STUDY UNDER FIELD CONDITIONS IN ECUADOR
TOPICAL TREATMENT OF AMERICAN CUTANEOUS LEISHMANIASIS WITH PARAMOMYCIN AND METHYLBENZETHONIUM CHLORIDE - A CLINICAL-STUDY UNDER FIELD CONDITIONS IN ECUADOR
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DOI：
10.1016/0035-9203(94)90517-7
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发表时间：
1994-01-01
影响因子：
2.2
通讯作者：
KROEGER, A
中科院分区：
文献类型：
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作者：
KRAUSE, G;KROEGER, A
来自厄瓜多尔太平洋沿岸的52例美国皮肤利什曼病（ACL）患者局部使用含有15%帕龙霉素（PR）和12%甲基苄索氯铵（MBCL）的白凡士林（白色软石蜡;白色凡士林）软膏进行治疗。在20次应用后（超过10或20天），所有病变在前100天内均显示完全上皮化。在一年的观察期内，5例患者发生了新的病变;其中2例可能是再感染。5例均为治疗失败，50 d后愈合率为72%，100 d后愈合率为90%，360 d后愈合率为85%。在同一地区的另一项研究中，一组23名患者3个月没有接受治疗。50 d后仅有9%的患者自行愈合。在治疗开始时观察病变的生长、炎症和疼痛。治疗后大部分病灶迅速愈合，无瘢痕。该药物被患者很好地接受，并且在热带野外条件下易于给药。
Fifty-two patients with American cutaneous leishmaniasis (ACL) from the Pacific coast of Ecuador were treated topically with an ointment containing 15% paramomycin (PR) and 12% methylbenzethonium chloride (MBCL) in vaselinum album (white soft paraffin; white petrolatum). After 20 applications (over 10 or 20 d) all lesions showed complete epithlialization within the first 100 d. Five patients developed new lesions during the one year observation period; 2 of these were probably reinfections. Considering all 5 cases as treatment failures, the healing rates were: 72% after 50 d, 90% after 100 d, and 85% after 360 d. In a separate study in the same area, a group of 23 patients was left without treatment for 3 months. Only 9% of the untreated patients healed spontaneously after 50 d. Growth of the lesion, inflammation and pain were observed at the beginning of treatment. After treatment, most lesions healed rapidly without scars. The drug was well accepted by the patients and was easy to administer under tropical field conditions.