Zika virus infection in pregnancy: a systematic review of disease course and complications.
Zika virus infection in pregnancy: a systematic review of disease course and complications.
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妊娠期寨卡病毒感染：病程和并发症的系统评价。
DOI：
10.1186/s12978-017-0285-6
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发表时间：
2017-02-28
影响因子：
3.4
通讯作者：
Oladapo OT
中科院分区：
文献类型：
--
作者：
Chibueze EC;Tirado V;Lopes KD;Balogun OO;Takemoto Y;Swa T;Dagvadorj A;Nagata C;Morisaki N;Menendez C;Ota E;Mori R;Oladapo OT
确定母体寨卡病毒(ZIKV)感染的特征，并补充世卫组织在ZIKV感染背景下的妊娠管理临时指南的证据基础。我们检索了从成立到2016年3月的相关数据库。两位综述作者独立筛选和评估了符合条件的报告全文，并从相关研究中提取了数据。研究质量分别使用纽卡斯尔-渥太华量表(NOS)和国家卫生研究所(NIH)观察性研究和病例系列/报告工具进行评估。在142篇符合条件的全文文章中，18篇符合纳入标准(13个病例系列/报告和5个队列研究)。疑似/确诊ZIKV感染的孕妇的常见症状是发热、皮疹和关节痛。在感染寨卡病毒的母亲中报告了1例格林-巴利综合征，没有其他报告的严重孕产妇发病率或死亡率病例。报告的与母体ZIKV感染相关的并发症包括广泛的胎儿和新生儿神经和眼睛异常；胎儿生长受限、死产和围产儿死亡。小头畸形是在8项研究中报告的主要神经并发症，在一项研究中，感染ZIKV的妇女的新生儿发病率约为1%。鉴于与产前寨卡病毒感染相关的广泛和多变的胎儿和新生儿表现/并发症，以及所提供的信息匮乏，知识差距是显而易见的。进一步的研究和全面的报告可能有助于更好地了解孕期寨卡病毒感染及伴随而来的母婴并发症。这些知识可以帮助制定有效的、以证据为基础的战略、指南和建议，以管理母亲寨卡病毒感染。在母体寨卡病毒感染的情况下，鼓励卫生服务提供者遵守目前的产前护理最佳做法指南。本文的在线版本(doi：10.1186/s12978-0170285-6)包含补充材料，授权用户可以使用。
To characterize maternal Zika virus (ZIKV) infection and complement the evidence base for the WHO interim guidance on pregnancy management in the context of ZIKV infection. We searched the relevant database from inception until March 2016. Two review authors independently screened and assessed full texts of eligible reports and extracted data from relevant studies. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS) and the National Institute of Health (NIH) tool for observational studies and case series/reports, respectively. Among 142 eligible full-text articles, 18 met the inclusion criteria (13 case series/reports and five cohort studies). Common symptoms among pregnant women with suspected/confirmed ZIKV infection were fever, rash, and arthralgia. One case of Guillain-Barré syndrome was reported among ZIKV-infected mothers, no other case of severe maternal morbidity or mortality reported. Complications reported in association with maternal ZIKV infection included a broad range of fetal and newborn neurological and ocular abnormalities; fetal growth restriction, stillbirth, and perinatal death. Microcephaly was the primary neurological complication reported in eight studies, with an incidence of about 1% among newborns of ZIKV infected women in one study. Given the extensive and variable fetal and newborn presentations/complications associated with prenatal ZIKV infection, and the dearth of information provided, knowledge gaps are evident. Further research and comprehensive reporting may provide a better understanding of ZIKV infection in pregnancy and attendant maternal/fetal complications. This knowledge could inform the creation of effective and evidence-based strategies, guidelines and recommendations aimed at the management of maternal ZIKV infection. Adherence to current best practice guidelines for prenatal care among health providers is encouraged, in the context of maternal ZIKV infection. The online version of this article (doi:10.1186/s12978-017-0285-6) contains supplementary material, which is available to authorized users.