Adaptation of HIV-1 to human leukocyte antigen class I.
Adaptation of HIV-1 to human leukocyte antigen class I.
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DOI：
10.1038/nature07746
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发表时间：
2009-04-02
期刊：
影响因子：
64.8
通讯作者：
Goulder, Philip
中科院分区：
文献类型：
--
作者：
Kawashima, Yuka;Pfafferott, Katja;Frater, John;Matthews, Philippa;Payne, Rebecca;Addo, Marylyn;Gatanaga, Hiroyuki;Fujiwara, Mamoru;Hachiya, Atsuko;Koizumi, Hirokazu;Kuse, Nozomi;Oka, Shinichi;Duda, Anna;Prendergast, Andrew;Crawford, Hayley;Leslie, Alasdair;Brumme, Zabrina;Brumme, Chanson;Allen, Todd;Brander, Christian;Kaslow, Richard;Tang, James;Hunter, Eric;Allen, Susan;Mulenga, Joseph;Branch, Songee;Roach, Tim;John, Mina;Mallal, Simon;Ogwu, Anthony;Shapiro, Roger;Prado, Julia G.;Fidler, Sarah;Weber, Jonathan;Pybus, Oliver G.;Klenerman, Paul;Ndung'u, Thumbi;Phillips, Rodney;Heckerman, David;Harrigan, P. Richard;Walker, Bruce D.;Takiguchi, Masafumi;Goulder, Philip
人类免疫缺陷病毒（HIV）流行病的快速和广泛传播为见证涉及人类的宿主-病原体协同进化提供了难得的机会。一个焦点是编码人类白细胞抗原（HLA）的基因和编码HIV蛋白的基因之间的相互作用。HLA分子将HIV蛋白的片段（表位）呈递到受感染细胞的表面上，以使免疫识别和CD 8 + T细胞的杀伤成为可能;特定的HLA分子，如HLA-B*57、HLA-B*27和HLA-B*51，更有可能介导HIV感染的成功控制。这些表位内的突变可允许病毒逃避CD 8 + T细胞识别。在这里，我们分析了来自5大洲9个不同研究队列的2,800多名受试者的病毒序列和HLA等位基因。对HLA-B*51限制性表位TAFTIPSI（逆转录酶残基128-135）的初步分析显示，在9个研究队列中，逃逸突变I135 X的频率与HLA-B*51患病率之间存在强相关性（P = 0.0001）。将这些分析扩展到纳入其他明确定义的CD 8 + T细胞表位，包括受HLA-B*57和HLA-B*27限制的表位，表明这些表位变体的频率（n = 14）与不同队列中限制性HLA等位基因的流行率一致相关（一起，P < 0.0001），证明了HIV在人群水平上适应HLA的强有力证据。这种病毒适应的过程可能会破坏与关键表位可用性相关的HIV感染控制的良好HLA关联，并突出了疫苗跟上HIV所呈现的不断变化的免疫格局的挑战。
The rapid and extensive spread of the human immunodeficiency virus (HIV) epidemic provides a rare opportunity to witness host–pathogen co-evolution involving humans. A focal point is the interaction between genes encoding human leukocyte antigen (HLA) and those encoding HIV proteins. HLA molecules present fragments (epitopes) of HIV proteins on the surface of infected cells to enable immune recognition and killing by CD8+ T cells; particular HLA molecules, such as HLA-B*57, HLA-B*27 and HLA-B*51, are more likely to mediate successful control of HIV infection. Mutation within these epitopes can allow viral escape from CD8+ T-cell recognition. Here we analysed viral sequences and HLA alleles from >2,800 subjects, drawn from 9 distinct study cohorts spanning 5 continents. Initial analysis of the HLA-B*51-restricted epitope, TAFTIPSI (reverse transcriptase residues 128–135), showed a strong correlation between the frequency of the escape mutation I135X and HLA-B*51 prevalence in the 9 study cohorts (P = 0.0001). Extending these analyses to incorporate other well-defined CD8+ T-cell epitopes, including those restricted by HLA-B*57 and HLA-B*27, showed that the frequency of these epitope variants (n = 14) was consistently correlated with the prevalence of the restricting HLA allele in the different cohorts (together, P < 0.0001), demonstrating strong evidence of HIV adaptation to HLA at a population level. This process of viral adaptation may dismantle the well-established HLA associations with control of HIV infection that are linked to the availability of key epitopes, and highlights the challenge for a vaccine to keep pace with the changing immunological landscape presented by HIV.
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CTL逃生变体的传播和积累驱动HIV多态性与HLA之间的负相关。
影响因子：
15.3
作者：
Leslie, A;Kavanagh, D;Honeyborne, I;Pfafferott, K;Edwards, C;Pillay, T;Hilton, L;Thobakgale, C;Ramduth, D;Draenert, R;Le Gall, S;Luzzi, G;Edwards, A;Brander, C;Sewell, AK;Moore, S;Mullins, J;Moore, C;Mallal, S;Bhardwaj, N;Yusim, K;Phillips, R;Klenerman, P;Korber, B;Kiepiela, P;Walker, B;Goulder, P
通讯作者：
Goulder, P
影响因子：
64.8
作者：
Goulder, PJR;Brander, C;Walker, BD
通讯作者：
Walker, BD
影响因子：
5.4
作者：
Tang, JM;Tang, SH;Kaslow, RA
通讯作者：
Kaslow, RA
影响因子：
1.8
作者：
Agresti, A;Coull, BA
通讯作者：
Coull, BA
DOI：
10.1084/jem.20072457
发表时间：
2008-05-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Goepfert PA;Lumm W;Farmer P;Matthews P;Prendergast A;Carlson JM;Derdeyn CA;Tang J;Kaslow RA;Bansal A;Yusim K;Heckerman D;Mulenga J;Allen S;Goulder PJ;Hunter E
通讯作者：
Hunter E