Douching, Talc Use, and Risk of Ovarian Cancer.
Douching, Talc Use, and Risk of Ovarian Cancer.
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DOI：
10.1097/ede.0000000000000528
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Weinberg CR
中科院分区：
文献类型：
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作者：
Gonzalez NL;O'Brien KM;D'Aloisio AA;Sandler DP;Weinberg CR
最近有报道称，冲洗与内分泌干扰性邻苯二甲酸盐的尿代谢物水平升高有关，但还没有关于冲洗与卵巢癌相关的文献。许多关于生殖器使用滑石粉的病例对照研究报告了卵巢癌风险的增加，但前瞻性队列研究并未统一证实这种联系。滑石粉的使用和冲洗之间的行为关联可能会产生混淆。姐妹研究(2003-2009)招募并跟踪了美国和波多黎各50884名姐妹被诊断患有乳腺癌的女性。在基线上，参与者被问及前12个月的冲洗和滑石粉使用情况。在随访期间(中位数为6.6年)，154名参与者报告了卵巢癌的诊断。我们使用Cox比例风险模型计算了卵巢癌风险的调整风险比(HR)和95%可信区间(CI)。会阴滑石粉的基线使用与随后的卵巢癌之间几乎没有关联(HR：0.73CI：0.44，1.2)。冲洗在滑石粉使用者中更常见(OR：2.1CI：2.0，2.3)，基线冲洗与卵巢癌的后续风险增加相关(HR：1.9CI：1.2，2.8)。在Sister的研究中，冲洗而不是使用滑石粉与卵巢癌风险增加有关。
Douching was recently reported to be associated with elevated levels of urinary metabolites of endocrine disrupting phthalates, but there is no literature on douching in relation to ovarian cancer. Numerous case-control studies of genital talc use have reported an increased risk of ovarian cancer, but prospective cohort studies have not uniformly confirmed this association. Behavioral correlation between talc use and douching could produce confounding. The Sister Study (2003–2009) enrolled and followed 50,884 women in the US and Puerto Rico who had a sister diagnosed with breast cancer. At baseline participants were asked about douching and talc use during the previous 12 months. During follow-up (median of 6.6 years) 154 participants reported a diagnosis of ovarian cancer. We computed adjusted hazard ratios (HR) and 95% confidence intervals (CI) for ovarian cancer risk using the Cox proportional hazards model. There was little association between baseline perineal talc use and subsequent ovarian cancer (HR: 0.73 CI: 0.44, 1.2). Douching was more common among talc users (OR: 2.1 CI: 2.0, 2.3), and douching at baseline was associated with increased subsequent risk of ovarian cancer (HR: 1.9 CI: 1.2, 2.8). Douching but not talc use was associated with increased risk of ovarian cancer in the Sister Study.