Oxytocin receptor gene polymorphisms moderate the relationship between job stress and general trust in Chinese Han university teachers
Oxytocin receptor gene polymorphisms moderate the relationship between job stress and general trust in Chinese Han university teachers
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催产素受体基因多态性调节中国汉族大学教师工作压力与普遍信任之间的关系
DOI：
10.1016/j.jad.2019.08.080
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发表时间：
2020-01-01
影响因子：
6.6
通讯作者：
He, Shuchang
中科院分区：
文献类型：
--
作者：
Fang, Yuan;Li, Zheneng;He, Shuchang
背景：长期暴露于紧张的工作环境会影响一般的信任。高工作压力与对他人的低信任有关。环境因素和遗传因素都对一般信任有影响，但很少有实证研究探讨基因-环境交互作用对一般信任的重要作用。本研究旨在探讨OXTR rs 53576和OXTR rs 2268490基因多态性在工作压力与一般信任关系中的调节作用。采用一般人口学特征、工作压力、一般信任量表等标准化问卷进行调查。结果：工作压力对一般信任有显著负主效应（p < 0.001），而对一般信任无显著负主效应（p > 0.05）。工作压力和OXTR rs 53576或rs 2268490之间的交互作用对一般信任的影响是显着的，即使在控制了性别和年龄。高工作压力与OXTR rs 53576纯合子个体（GG/AA）或OXTR rs 2268490 CT个体的低一般信任相关，表明OXTR rs 53576中的GA基因型和OXTR rs 2268490中的CC/TT基因型是一般信任的保护性基因型。本研究采用横断面设计，仅考虑中国汉族大学教师，仅检测了OXTR的两个多态性。我们的研究结果提供的证据表明，基因-环境相互作用影响一般的信任，并确定了一个新的基因座（rs 2268490）的表型。
Background: Chronic exposure to stressful work environments can influence general trust. High job stress is associated with low trust in others. Both environmental and genetic factors contribute to general trust; however, few empirical studies have explored the important role of gene-environment interactions on general trust. In this study, the moderating roles of the polymorphisms OXTR rs53576 and OXTR rs2268490 in the relationship between job stress and general trust were evaluated.Methods: 362 healthy Chinese Han university teachers (196 males, 165 females, and 1 undisclosed) were included (M-age = 39.80, SD = 9.16). Standardized questionnaires about demographic characteristics, job stress, and general trust scale were collected. Blood samples were collected for OXTR rs53576 and rs2268490 genotyping.Results: Job stress scores showed a significant negative main effect on general trust (p < 0.001), while OXTR rs53576 and rs2268490 did not (p > 0.05). The effect of the interaction between job stress and OXTR rs53576 or rs2268490 on general trust was significant, even after controlling for gender and age. High job stress was associated with low general trust in OXTR rs53576 homozygous individuals (GG/AA) or OXTR rs2268490 CT individuals, demonstrating that the GA genotype in OXTR rs53576 and CC/TT genotype in OXTR rs2268490 are protective genotype of general trust.Limitations: This study used a cross-sectional design, only considered Chinese Han university teachers, and only examined two polymorphisms in OXTR.Conclusions: Our findings provide evidence that gene-environment interactions influence general trust and identify a new locus (rs2268490) underlying this phenotype.