Unraveling the Relationship between Motor Symptoms, Affective States and Contextual Factors in Parkinson's Disease: A Feasibility Study of the Experience Sampling Method.
Unraveling the Relationship between Motor Symptoms, Affective States and Contextual Factors in Parkinson's Disease: A Feasibility Study of the Experience Sampling Method.
复制标题
揭示帕金森病运动症状、情感状态和情境因素之间的关系：经验抽样方法的可行性研究。
DOI：
10.1371/journal.pone.0151195
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Leentjens AF
中科院分区：
文献类型：
--
作者：
Broen MP;Marsman VA;Kuijf ML;Van Oostenbrugge RJ;van Os J;Leentjens AF
在帕金森病（PD）中，运动症状、情感状态和背景因素之间的复杂关系仍有待阐明。经验抽样法为解决这一问题提供了一种新的方法.使用带有特殊用途应用程序（app）的移动终端，在日常生活流中的随机时刻重复评估运动症状、情感状态和背景因素，产生症状和体验的密集时间序列。本研究的目的是研究这种方法的可行性。我们研究了为期五天的ESM在PD和它的能力，以客观的运动症状严重程度的昼夜波动和他们的关系与影响和上下文因素在5个PD患者的运动波动的可行性。参与者达到了很高的依从性，84%的评估时刻在不干扰日常活动的情况下完成。在10分量表中，器械的效用被评为8分。我们能够捕捉到常规临床评估未发现的广泛的昼夜波动。此外，我们能够在个体内部水平上检测运动症状、情绪波动和背景因素之间的临床相关性。ESM代表了一种可行的和新颖的方法来阐明运动症状，情感状态和情境因素之间的关系，在个体的水平。ESM为临床实践和科学研究带来了希望。
In Parkinson's disease (PD), the complex relationship between motor symptoms, affective states, and contextual factors remains to be elucidated. The Experience Sampling Method provides (ESM) a novel approach to this issue. Using a mobile device with a special purpose application (app), motor symptoms, affective states and contextual factors are assessed repeatedly at random moments in the flow of daily life, yielding an intensive time series of symptoms and experience. The aim of this study was to study the feasibility of this method. We studied the feasibility of a five-day period of ESM in PD and its ability to objectify diurnal fluctuations in motor symptom severity and their relation with affect and contextual factors in five PD patients with motor fluctuations. Participants achieved a high compliance, with 84% of assessment moments completed without disturbance of daily activities. The utility of the device was rated 8 on a 10-point scale. We were able to capture extensive diurnal fluctuations that were not revealed by routine clinical assessment. In addition, we were able to detect clinically relevant associations between motor symptoms, emotional fluctuations and contextual factors at an intra-individual level. ESM represents a viable and novel approach to elucidate relationships between motor symptoms, affective states and contextual factors at the level of individual subjects. ESM holds promise for clinical practice and scientific research.