Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies.
Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies.
复制标题
免疫机制在诱导 HIV-1 广泛中和抗体中的作用。
DOI：
10.1016/j.coi.2011.04.003
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发表时间：
2011
影响因子：
7
通讯作者：
Haynes,BartonF
中科院分区：
文献类型：
--
作者：
Verkoczy,Laurent;Kelsoe,Garnett;Moody,MAnthony;Haynes,BartonF
虽然HIV-1感染或免疫可以引起抗体，但在大多数个体中无法检测到那些广泛中和的抗体（bnAbs），即使它们在HIV-1感染中出现，也只有在传播数年后才会出现。直到最近，难以诱导这种bnab的原因还不清楚。最近从罕见患者中分离bnAbs的技术进步增加了我们对其特异性和特征的了解，并且随着基因靶向研究的开展，也开始发现免疫调节障碍阻止其诱导的证据。开发有效的HIV-1疫苗的一个关键途径是利用这些新出现的信息来合理设计免疫原和配制佐剂，从而克服常规诱导bnAbs的结构和免疫障碍。
Although antibodies can be elicited by HIV-1 infection or immunization, those that are broadly neutralizing (bnAbs) are undetectable in most individuals, and when they do arise in HIV-1 infection, only do so years after transmission. Until recently, the reasons for difficulty in inducing such bnAbs have been obscure. Recent technological advances in isolating bnAbs from rare patients have increased our knowledge of their specificities and features, and along with gene-targeting studies, have also begun uncovering evidence of immunoregulatory roadblocks preventing their induction. One crucial avenue towards developing an effective HIV-1 vaccine is to harness this emerging information into the rational design of immunogens and formulation of adjuvants, such that structural and immunological hurdles to routinely eliciting bnAbs can be overcome.