[Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia].
[Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia].
复制标题
维生素K2制剂对合并骨质减少的重度残疾患者的作用[J].
DOI：
--
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
M. Hasui
中科院分区：
文献类型：
--
作者：
H. Tsuji;K. Honke;M. Hasui
对20例因严重精神和/或身体残疾而长期住院的可能继发性骨质疏松症的儿童和成人口服维生素K2治疗的疗效和副作用进行了研究。服用维生素K2 12个月。开始口服维生素K2治疗后4个月，骨密度显著增加（p = 0.0038），治疗12个月后，骨密度仍保持较高水平。这种疗法对严重运动功能障碍的患者特别有效。血清总蛋白水平显着降低后，开始这种治疗（p = 0.0012）。这种下降的原因及其与维生素K2给药的因果关系尚不清楚，应进一步研究。
The efficacy and side effects of oral vitamin K2 therapy were examined in 20 children and adults with probable secondary osteoporosis who had been hospitalized for a long period, due to severe mental and/or physical handicaps. Vitamin K2 was given for 12 months. Bone mineral density significantly increased 4 months after starting oral vitamin K2 therapy (p = 0.0038) and it retained the elevated level after 12 months of treatment. This therapy was particularly effective in patients with severe locomotor dysfunction. Serum total protein levels significantly decreased following the start of this therapy (p = 0.0012). The reasons of this decrease and its causal relationship to the administration of vitamin K2 are unknown, and should be investigated further.