Potential basis for amphotericin B resistance in Aspergillus terreus
Potential basis for amphotericin B resistance in Aspergillus terreus
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DOI：
10.1128/aac.01280-07
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发表时间：
2008-04-01
影响因子：
4.9
通讯作者：
Lass-Floerl, Cornelia
中科院分区：
文献类型：
--
作者：
Blum, Gerhard;Perkhofer, Susanne;Lass-Floerl, Cornelia
本研究探讨了土曲霉内生两性霉素B （AMB）抗性的基础。麦角甾醇含量、细胞壁组成和脂质过氧化水平对AMB抗性没有影响。土霉过氧化氢酶产量显著高于烟曲霉（P < 0.05）。由于氧化损伤与AMB的作用有关，这种高水平的产生可能有助于AMB的抗性。
This study investigated the basis for intrinsic amphotericin B (AMB) resistance in Aspergillus terreus. The ergosterol content, cell wall composition, and lipid peroxidation level had no influence on AMB resistance. The level of catalase production in A. terreus was significantly higher than that in A. fumigatus (P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action.