Antimicrobial resistance data on 16,756 Streptococcus pneumoniae isolates in 1999:: A pan-regional multicenter surveillance study in France
Antimicrobial resistance data on 16,756 Streptococcus pneumoniae isolates in 1999:: A pan-regional multicenter surveillance study in France
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DOI：
10.1089/mdr.2005.11.323
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发表时间：
2005-12-01
影响因子：
2.6
通讯作者：
Ploy, MC
中科院分区：
文献类型：
--
作者：
Demachy, MC;Vernet-Garnier, V;Ploy, MC
耐抗生素肺炎链球菌患病率上升是世界各地不同程度观察到的现象。目前的国家监测研究报告分析了1999年在法国收集的总共16,756株肺炎链球菌。对青霉素敏感性降低的肺炎链球菌的总体患病率为44%，对阿莫西林为26%，对头孢噻肟为17%。青霉素（MIC > 1 mg/L）、阿莫西林和头孢噻肟（MIC > 2 mg/L）高水平耐药菌株比例仍然较低，分别为12.3%、1.8%和0.4%。对其他抗生素的耐药率很高：红霉素耐药率为 53%，复方新诺明耐药率为 41.7%，四环素耐药率为 31.8%，氯霉素耐药率为 24.6%。耐青霉素肺炎链球菌的患病率根据受试者年龄和标本来源而变化。儿童（52.7%）高于成人（39.8%），中耳液分离菌株（63.6%）高于儿童血培养菌株（41.8%）。尽管数据显示出地域差异，但肺炎链球菌对其他抗生素产生耐药性在儿童中比在成人中更为常见。与 1997 年在同一地区进行的一项研究相比，证实了耐药细菌的流行呈上升趋势。因此，我们得出的结论是，1999年法国耐抗生素肺炎链球菌的流行率继续上升，尽管对青霉素高度耐药的菌株保持稳定。
The rising prevalence of antibiotic-resistant Streptococcus pneumoniae is a phenomenon observed to different degrees around the world. The present national surveillance study report analyzes a total of 16,756 strains of S. pneumoniae collected across France in 1999. The overall prevalence of S. pneumoniae with decreased susceptibility to penicillin was 44%, to amoxicillin 26%, and to cefotaxime 17%. The proportion of high-level resistant strains to penicillin (MIC > 1 mg/L), amoxicillin and cefotaxime (MIC > 2 mg/L) remained low: 12.3%, 1.8%, and 0.4% respectively. Prevalence of resistance to other antibiotics was high: 53% to erythromycin, 41.7% to cotrimoxazole, 31.8% to tetracycline, and 24.6% to chloramphenicol. Prevalence of penicillin-resistant S. pneumoniae varied according to subject age and specimen source. It was higher in children (52.7%) than in adults (39.8%) and higher in strains isolated from middle ear fluid (63.6%) than from blood cultures(41.8%) in children. S. pneumoniae resistant to other antibiotics were more common in children than in adults, although figures showed geographical variations. Comparison with a previous study realized in 1997 in the same regions confirms a rising trend in the prevalence of resistant bacteria. Therefore, we conclude that prevalence of antibiotic-resistant S. pneumoniae in 1999 continued to rise in France, although strains with high-level resistance to penicillin remained stable.