Lymphotoxin in physiology of lymphoid tissues - Implication for antiviral defense.
Lymphotoxin in physiology of lymphoid tissues - Implication for antiviral defense.
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DOI：
10.1016/j.cyto.2016.08.018
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发表时间：
2018-01
期刊：
影响因子：
3.8
通讯作者：
Tumanov AV
中科院分区：
文献类型：
--
作者：
Koroleva EP;Fu YX;Tumanov AV
光敏素（LT）是细胞因子肿瘤坏死因子（TNF）超家族的成员，其具有多种功能，包括控制淋巴器官的发育和维持，以及调节炎症和自身免疫。虽然LT在器官发生和维持淋巴器官中的作用已经得到很好的确立，但LT途径在对病原体的免疫应答期间对淋巴器官稳态的贡献还不太清楚。本文就LT通路在抗病毒免疫应答中的作用作一综述。我们讨论了LT信号在淋巴器官的完整性，I型干扰素的生产和调节的保护和病毒感染过程中的免疫病理学的作用。我们进一步讨论了治疗靶向LT途径控制免疫病理学和抗病毒保护的潜力。
Lymphotoxin (LT) is a member of the tumor necrosis factor (TNF) superfamily of cytokines which serves multiple functions, including the control of lymphoid organ development and maintenance, as well as regulation of inflammation and autoimmunity. Although the role of LT in organogenesis and maintenance of lymphoid organs is well established, the contribution of LT pathway to homeostasis of lymphoid organs during the immune response to pathogens is less understood. In this review, we highlight recent advances on the role of LT pathway in antiviral immune responses. We discuss the role of LT signaling in lymphoid organ integrity, type I IFN production and regulation of protection and immunopathology during viral infections. We further discuss the potential of therapeutic targeting LT pathway for controlling immunopathology and antiviral protection.