Chiral bicyclic lactams: Useful precursors and templates for asymmetric syntheses
Chiral bicyclic lactams: Useful precursors and templates for asymmetric syntheses
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DOI：
10.1039/a604443c
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发表时间：
1997-01-07
影响因子：
4.9
通讯作者：
Brengel, GP
中科院分区：
文献类型：
--
作者：
Meyers, AI;Brengel, GP
提出了对实用双环内酰胺的调查，这些手性模板已经并将继续提供大量高对映体纯度的天然和非天然碳环产品，随着构建杂环的新方法的开发，它们的合成多功能性最近不断增长。除了环戊烯酮、环己烯酮和六氢茚酮系统外，衍生自双环内酰胺的产品现在还包括光学活性哌啶，吡咯烷、吡咯烷酮和四氢异喹啉。这些有利的特性使双环内酰胺成为高度适用的不对称合成工具。
A survey of the utilitarian bicyclic lactams is presented, These chiral templates have provided, and continue to provide, access to a plethora of natural and unnatural carbocyclic products in high enantiomeric purity, Their synthetic versatility has recently grown with the development of new methods for the construction of heterocycles, In addition to the cyclopentenone, cyclohexenone and hexahydroindenone systems, products derived from bicyclic lactams now include optically active piperidines, pyrrolidines, pyrrolidinones and tetrahydroisoquinolines. These favourable properties make the bicyclic lactams highly adaptable tools for asymmetric synthesis.