Early Phase PIB-PET as a Surrogate for Global and Regional Cerebral Blood Flow Measures
Early Phase PIB-PET as a Surrogate for Global and Regional Cerebral Blood Flow Measures
复制标题
DOI：
10.1111/jon.12582
复制
发表时间：
2019-01-01
影响因子：
2.4
通讯作者：
Schultz, Susan K.
中科院分区：
文献类型：
--
作者：
Ponto, Laura L. Boles;Moser, David J.;Schultz, Susan K.
背景和目的探讨[C-11]PIB摄取的简化测量作为脑血流量（CBF）测量的替代物的可能性，从而在同一扫描中提供病理和功能信息。方法参与者（N = 24，16名男性，8名女性，57-87岁）接受定量[O-15]水成像和动态[C-11]PIB成像。为每个参与者的区域[C-11]PIB数据创建时间-活性曲线，以标准化摄取值（SUV）进行缩放。定义每例受试者发生最大摄取的帧（即“峰值”）。测定3.5-4分钟时间间隔内和初始6分钟总和内个体峰值时每个区域的浓度（SUV）。确定每个区域的简化参考组织模型2的R1（即，使用小脑作为参考组织的相对递送）。将PIB SUV与绝对CBF全局和区域值（mL/min/100 mL）进行比较，并将R1值与小脑标准化rCBF进行比较。结果发现所有SUV测量值与绝对整体和局部CBF测量值之间存在显著的线性关系，与标准化CBF和R1之间的关系相当。个人SUV峰值表现出最强的区域和全球的关系。所有个体和所有区域的回归斜率都非常显著。年龄、性别或淀粉样蛋白负荷不影响这种关系。结论早期PIB摄取有可能有效地作为全球和区域CBF措施的替代品。简单和容易获得的个人的SUV峰值是最强的预测区域和全球的CBF。
BACKGROUND AND PURPOSE To explore the potential for simplified measures of [C-11]PIB uptake to serve as a surrogate for cerebral blood flow (CBF) measures, thereby, providing both pathological and functional information in the same scan. METHODS Participants (N = 24, 16 M, 8 F, 57-87 years) underwent quantitative [O-15]water imaging and dynamic [C-11]PIB imaging. Time-activity curves were created for each participant's regional [C-11]PIB data scaled in standardized uptake values (SUVs). The frame in which maximal uptake occurred was defined for each subject (ie, "peak"). The concentration (SUV) for each region at the individual's peak, during the 3.5-4 minute time interval and for the initial 6 minute sum, was determined. R1 (ie, relative delivery using cerebellum as reference tissue) from the simplified reference tissue model 2 was determined for each region. PIB SUVs were compared to the absolute CBF global and regional values (in mL/minute/100 mL) and the R1 values were compared to the cerebellar-normalized rCBF. RESULTS Significant linear relationships were found for all SUV measures with measures of absolute global and regional CBF that were comparable to the relationship between normalized CBF and R1. The individual SUVpeak exhibited the strongest relationship both regionally and globally. All individuals and all regions had highly significant regression slopes. Age, gender, or amyloid burden did not influence the relationship. CONCLUSION Early PIB uptake has the potential to effectively serve as a surrogate for global and regional CBF measures. The simple and readily obtainable individual's SUVpeak value was the strongest predictor regionally and globally of CBF.