Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model.
Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model.
复制标题
补偿机制调节红藻氨酸诱导的癫痫小鼠模型中的神经元兴奋性
DOI：
10.3389/fncir.2018.00048
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发表时间：
2018
影响因子：
3.5
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Pan G;Chen Z;Zheng H;Zhang Y;Xu H;Bu G;Zheng H;Li Y
Epilepsy is one of the most common neurological disorders affecting millions of people. Due to the complicated and unclear mechanisms of epilepsy, still a significant proportion of epilepsy patients remain poorly controlled. Epilepsy is characterized by convulsive seizures that are caused by increased excitability. In this study, by using kainic acid (KA)-induced epilepsy mice, we investigated the neuronal activities and revealed the neuronal compensatory mechanisms after KA-induced toxic hyperexcitability. The results indicate that both phasic inhibition induced by enhanced inhibitory synaptic activity and tonic inhibition mediated by activated astrocytes participate in the compensatory mechanisms. Compensatory mechanisms were already found in various neuronal disorders and were considered important in protecting nervous system from toxic hyperexcitability. This study hopefully will provide valuable clues in understanding the complex neuronal mechanisms of epilepsy, and exploring potential clinical treatment of the disease.
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影响因子：
3.5
作者：
Egawa K;Fukuda A
通讯作者：
Fukuda A
影响因子：
4.6
作者：
Yan R;Chen M;Zhou H;Liu T;Tang X;Zhang K;Zhu H;Ye J;Zhang D;Fan T
通讯作者：
Fan T
影响因子：
3.7
作者：
Laurén HB;Lopez-Picon FR;Brandt AM;Rios-Rojas CJ;Holopainen IE
通讯作者：
Holopainen IE
影响因子：
2.2
作者：
Caulder EH;Riegle MA;Godwin DW
通讯作者：
Godwin DW
影响因子：
5.3
作者：
Feng, HJ;Kang, JQ;Macdonald, RL
通讯作者：
Macdonald, RL