Is the optical rotation sign/absolute configuration relationship still a problem? Examples taken from unnatural quaternary aminoacids.
Is the optical rotation sign/absolute configuration relationship still a problem? Examples taken from unnatural quaternary aminoacids.
复制标题
旋光符号/绝对构型关系还存在问题吗？
DOI：
10.1002/chir.20296
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发表时间：
2006
期刊：
影响因子：
2
通讯作者：
J. Plaquevent
中科院分区：
文献类型：
--
作者：
L. Ferron;F. Guillen;Servane Coste;G. Coquerel;J. Plaquevent
由于在最近的文献中发现一些α -甲基- α -芳基甘氨酸的旋光符号/绝对构型关系不一致，因此用晶体学方法重新研究了它们的旋光符号/绝对构型关系。以前用酶解法类比天然叔胺基酸所作的分配，在这些季胺基酸的情况下被发现是错误的。
The optical rotation sign/absolute configuration relationships of several alpha-methyl-alpha-arylglycines have been reinvestigated by crystallographic methods, as they have been found to be inconsistent in recent literature. Assignments previously made by enzymatic resolution, by analogy with natural tertiary aminoacids were found to be erroneous in the case of these quaternary aminoacids.