In vivo EPR for dosimetry
In vivo EPR for dosimetry
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DOI：
10.1016/j.radmeas.2007.05.023
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发表时间：
2007-07-01
影响因子：
2
通讯作者：
Schauer, David A.
中科院分区：
文献类型：
--
作者：
Swartz, Harold M.;Burke, Greg;Schauer, David A.
由于恐怖主义、事故或战争，人群可能暴露于电离辐射剂量，可能在数天或数周内造成直接临床影响。目前迫切需要确定个人接触的程度，以便对有重大风险的人立即采取适当的程序，而对没有重大急性影响可能性的人则可以放心，并使他们不需要在医疗/紧急系统中作进一步的考虑。在许多合理的情况下，迫切需要在事件发生后不久，在受试者仍然在场时作出决定。对辐射引起的牙釉质变化进行体内EPR测量是一种方法，也许是唯一的这种方法，它可以区分剂量，足以将个人分类为治疗类别，并具有足够的准确性，以便于作出医疗决定。在其当前状态下，假设重复测量受试者口腔中的牙齿，体内EPR剂量计可以在辐射的急性生物效应的感兴趣范围内提供吸收剂量的估计值，误差约为+/-50cGy。随着谐振器以及用于获取和计算剂量的算法的改进，预期获取所需的时间、下限和精度将得到改善。目前使用的磁体系统虽然可能是可部署的，但有些大且重，需要将其安装在小型卡车或拖车上。包括口内磁铁在内的几种较小的磁铁正在开发中，这将提高该技术的易用性。(c)2007爱思唯尔有限公司保留所有权利。
As a result of terrorism, accident, or war, populations potentially can be exposed to doses of ionizing radiation that could cause direct clinical effects within days or weeks. There is a critical need to determine the magnitude of the exposure to individuals so that those with significant risk have appropriate procedures initiated immediately, while those without a significant probability of acute effects can be reassured and removed from the need for further consideration in the medical/emergency system. In many of the plausible scenarios there is an urgent need to make the determination very soon after the event and while the subject is still present. In vivo EPR measurements of radiation-induced changes in the enamel of teeth is a method, perhaps the only such method, which can differentiate among doses sufficiently for classifying individuals into categories for treatment, with sufficient accuracy to facilitate decisions on medical treatment. In its current state, the in vivo EPR dosimeter can provide estimates of absorbed dose with an error approximately +/- 50cGy over the range of interest for acute biological effects of radiation, assuming repeated measurements of the tooth in the mouth of the subject. The time required for acquisition, the lower limit, and the precision are expected to improve, with improvements in the resonator and the algorithm for acquiring and calculating the dose. The magnet system that is currently used, while potentially deployable, is somewhat large and heavy, requiring that it be mounted on a small truck or trailer. Several smaller magnets, including an intraoral magnet are under development, which would extend the ease of use of this technique. (c) 2007 Elsevier Ltd. All rights reserved.