Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study
Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study
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DOI：
10.1111/j.1365-2559.2012.04278.x
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发表时间：
2012-11-01
期刊：
影响因子：
6.4
通讯作者：
Sato, Kimiya
中科院分区：
文献类型：
--
作者：
Matsukuma, Susumu;Takeo, Hiroaki;Sato, Kimiya
目的：本研究试图阐明细胞角蛋白7（CK 7）异常表达的临床病理特征小叶中心hepatocellular hepatocyte.Methods and Results：共检测了113例常见非肿瘤性肝病患者的肝活检标本，包括B或C型肝炎、非酒精性脂肪性肝炎、酒精性肝病和其他疾病。在56例（49.6%）标本中，CK 7阳性小叶中心肝细胞（CK 7 + CHs）被鉴定，有时显示双核特征。CK 7 + CH与患者年龄较大相关（P = 0.004），血清天冬氨酸转氨酶水平升高（P = 0.016）和γ-谷氨酰转移酶（P = 0.006），小叶中心纤维化肝细胞板明显增厚（P < 0.001）与性别、脂肪变性、血清总胆红素和丙氨酸氨基转移酶水平无关。在55例单纯B型肝炎和C型肝炎患者中，CK 7 + CHs与较高的肝纤维化分期有关（P = 0.006）。结论：CK 7 + CHs在非肿瘤性肝病中相对较常见，与小叶中心瘢痕形成和CK 7阳性门静脉周围肝细胞的存在有关，在病因学方面似乎是一种非特异性现象。CK 7 + CHs可能代表肝祖细胞的年龄依赖性激活或肝细胞本身的再生现象，这两者都可能有助于肝再生。
Aims: This study has attempted to elucidate the clinicopathological features of aberrant cytokeratin 7 (CK7) expression by centrilobular hepatocytes.Methods and results: A total of 113 liver biopsy specimens from patients with common non-neoplastic liver diseases, including hepatitis B or C, non-alcoholic steatohepatitis, alcoholic liver disease and other diseases were examined. In 56 specimens (49.6%), CK7-positive centrilobular hepatocytes (CK7 + CHs) were identified and sometimes showed binuclear features. CK7 + CHs were associated with patients older age (P = 0.004), higher serum levels of aspartate aminotransferase (P = 0.016) and gamma-glutamyltransferase (P = 0.006), centrilobular fibrosis (P < 0.001), prominent thickening of hepatocytic plates (P < 0.001) and higher scores of total and periportal CK7-positive hepatocytes (both P < 0.001), but were not correlated with gender, steatosis, serum levels of total bilirubin or alanine aminotransferase. In 55 cases of hepatitis B and hepatitis C only, CK7 + CHs were related to a higher stage of fibrosis (P = 0.006).Conclusion: CK7 + CHs occur relatively frequently in non-neoplastic liver disease, associated with centrilobular scarring and the presence of CK7-positive periportal hepatocytes, and appear to be a non-specific phenomenon with respect aetiology of underlying disease. CK7 + CHs may represent age-dependent activation of hepatic progenitor cells or a regenerative phenomenon of hepatocytes themselves, both of which might contribute to liver regeneration.