Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry
Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry
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DOI：
10.1007/s00406-004-0522-1
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发表时间：
2004-12-01
影响因子：
4.7
通讯作者：
Kurachi, M
中科院分区：
文献类型：
--
作者：
Kawasaki, Y;Suzuki, M;Kurachi, M
精神分裂症的脑异常可能包括与易感性有关的偏差和与显性精神病相关的病理变化。我们对临床精神分裂症和分裂型精神障碍患者的大脑形态进行了横断面比较，分裂型精神障碍是一种没有华丽精神病发作的精神分裂症谱系障碍。应用基于体素的形态计量学方法对25例精神分裂症患者、25例分裂型障碍患者和50例健康受试者的灰质体积进行了测量。与对照组相比，精神分裂症患者双侧额叶内侧、额叶下部、颞叶内侧和隔区，左侧额叶中段、眶前叶、岛叶和颞叶上区灰质减少，左侧基底节灰质增多。分裂型障碍患者表现为左侧额叶下部、脑岛、颞叶上部和内侧颞叶区域减少。与分裂型精神障碍相比，精神分裂症患者的左眶额区显著减少。两组患者常见的灰质减少，如左侧内侧颞叶和下额叶区域的灰质减少可能代表精神分裂症的易感性，几个额叶区域的额外参与可能是花斑性精神病的关键。
Brain abnormalities of schizophrenia probably consist of deviation related to the vulnerability and pathological changes in association with overt psychosis. We conducted a cross-sectional comparison in brain morphology between patients with overt schizophrenia and schizotypal disorder, a schizophrenia-spectrum disorder without florid psychotic episode. Voxel-based morphometry was applied to assess gray matter volume in 25 patients with schizophrenia, 25 patients with schizotypal disorder, and 50 healthy control subjects. In comparison with controls, schizophrenia patients showed gray matter reductions in the bilateral medial frontal, inferior frontal, medial temporal, and septal regions, and the left middle frontal, orbitofrontal, insula, and superior temporal regions, and an increased gray matter in the left basal ganglia. Schizotypal disorder patients showed reductions in the left inferior frontal, insula, superior temporal, and medial temporal regions. There was a significant reduction in the left orbitofrontal region of schizophrenia compared with schizotypal disorder. Gray matter reductions that are common to both patient groups such as those in the left medial temporal and inferior frontal regions may represent vulnerability to schizophrenia, and additional involvement of several frontal regions may be crucial to florid psychosis.