Expression of c‐FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease
Expression of c‐FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease
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DOI：
10.1111/j.1365-2230.2011.04238.x
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发表时间：
2012-04
影响因子：
4.1
通讯作者：
F. Tian;J. Lu;L. Wang;L Li-;J. Yang;Y. Li;Y. Liu;G. Shen;Y. Tu;J. Tao
中科院分区：
文献类型：
--
作者：
F. Tian;J. Lu;L. Wang;L Li-;J. Yang;Y. Li;Y. Liu;G. Shen;Y. Tu;J. Tao
背景。许多分子事件与恶性黑色素瘤（MM）的发展有关。细胞FLICE样抑制蛋白（c‐FLIP）最初被确定为通过与FADD样白细胞间素- 1β转换酶（FLICE，也称为caspase‐8）竞争而募集到FAS相关死亡结构域（FADD）的死亡受体信号的抑制剂，最近有研究表明，c‐FLIP是各种细胞类型的生存和增殖所必需的。
Background. Numerous molecular events have been associated with the development of malignant melanoma (MM). The cellular FLICE‐like inhibitory protein (c‐FLIP) was originally identified as an inhibitor of death‐receptor signalling through competition with FADD‐like interleukin‐1β‐converting enzyme (FLICE; also known as caspase‐8) for recruitment to the FAS‐associated death domain (FADD), and it has been suggested recently that c‐FLIP is required for the survival and proliferation of various cell types.