LENGTHS OF CHROMOSOMAL SEGMENTS CONSERVED SINCE DIVERGENCE OF MAN AND MOUSE
LENGTHS OF CHROMOSOMAL SEGMENTS CONSERVED SINCE DIVERGENCE OF MAN AND MOUSE
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DOI：
10.1073/pnas.81.3.814
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
TAYLOR, BA
中科院分区：
文献类型：
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作者：
NADEAU, JH;TAYLOR, BA
利用人和小鼠同源基因座的连锁关系估计了进化过程中保守的常染色体片段的平均长度。比较83个以上同源位点的位置，发现13个保守片段。这13个片段的最外标记之间的地图距离对于小鼠是已知的，范围从1到24厘摩。开发了使用该保守片段样本来估计基因组中所有保守常染色体片段的平均长度的方法。该平均长度估计为8.1 +/- 1.6厘摩。证据表明，染色体重排，确定这些片段的长度是随机分布在基因组内。保守片段的估计平均长度被用来预测某些基因座，如肽酶-3和肾素，在人类中连锁的概率，因为同源基因座在小鼠中相距千分之一厘摩。保守片段的平均长度也被用来估计染色体重排的数量，这些重排破坏了人类和小鼠分化后的连锁。这一估计数显示为178 +/- 39次重排。
Linkage relationships of homologous loci in man and mouse were used to estimate the mean length of autosomal segments conserved during evolution. Comparison of the locations of greater than 83 homologous loci revealed 13 conserved segments. Map distances between the outermost markers of these 13 segments are known for the mouse and range from 1 to 24 centimorgans. Methods were developed for using this sample of conserved segments to estimate the mean length of all conserved autosomal segments in the genome. This mean length was estimated to be 8.1 +/- 1.6 centimorgans. Evidence is presented suggesting that chromosomal rearrangements that determine the lengths of these segments are randomly distributed within the genome. The estimated mean length of conserved segments was used to predict the probability that certain loci, such as peptidase-3 and renin, are linked in man given that homologous loci are chi centimorgans apart in the mouse. The mean length of conserved segments was also used to estimate the number of chromosomal rearrangements that have disrupted linkage since divergence of man and mouse. This estimate was shown to be 178 +/- 39 rearrangements.